Hou Wenjia, Shi Guorui, Wu Songze, Mo Jiayi, Shen Lan, Zhang Xiuqiang, Zhu Yabin
School of Medicine, Ningbo University, Ningbo, China.
Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China.
Front Microbiol. 2022 Jul 14;13:957698. doi: 10.3389/fmicb.2022.957698. eCollection 2022.
Antimicrobial photodynamic inactivation (aPDI) is a newly emerged treatment approach that can effectively address the issue of multidrug resistance resulting from the overuse of antibiotics. Fullerenes can be used as promising photosensitizers (PSs) for aPDI due to the advantages of high triplet state yields, good photostability, wide antibacterial spectrum, and permissibility of versatile functionalization. This review introduces the photodynamic activities of fullerenes and the up-to-date understanding of the antibacterial mechanisms of fullerene-based aPDI. The most recent works on the functionalization of fullerenes and the application of fullerene derivatives as PSs for aPDI are also summarized. Finally, certain remaining challenges are emphasized to provide guidance on future research directions for achieving clinical application of fullerene-based aPDI.
抗菌光动力灭活（aPDI）是一种新出现的治疗方法，能够有效解决因抗生素过度使用导致的多重耐药性问题。由于具有高三重态产率、良好的光稳定性、广谱抗菌性以及多功能化的可行性等优点，富勒烯可作为aPDI颇具前景的光敏剂（PSs）。本综述介绍了富勒烯的光动力活性以及对基于富勒烯的aPDI抗菌机制的最新认识。还总结了富勒烯功能化的最新研究成果以及富勒烯衍生物作为aPDI的PSs的应用。最后，强调了某些尚存的挑战，为实现基于富勒烯的aPDI临床应用的未来研究方向提供指导。
