Huang Yaun-Chao, Hwang Tsong-Long, Chang Chih-Shiang, Yang Yu-Liang, Shen Chia-Ning, Liao Wen-Ying, Chen Sheng-Chih, Liaw Chih-Chuang
Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung 404, Taiwan, Republic of China.
J Nat Prod. 2009 Jul;72(7):1273-8. doi: 10.1021/np900148a.
Eight new prenylated flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4'-dihydroxy-4'',4''-dimethyl-5''-methyl-5''H-dihydrofurano[2'',3'':6,7]flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (FMLP/CB).
从七指蕨的根茎中分离并纯化出了8个新的异戊烯基黄酮类化合物，即乌冈宁M-T（1-8），以及5个已知化合物，乌冈宁J-L（9-11）、5,4'-二羟基-4'',4''-二甲基-5''-甲基-5''H-二氢呋喃并[2'',3'':6,7]黄烷酮和槲皮素。通过光谱学和化学方法阐明了新分离化合物的结构。化合物1、3、5、7、8和11对人中性粒细胞在受到甲酰-L-蛋氨酰-L-亮氨酰-L-苯丙氨酸/细胞松弛素B（FMLP/CB）刺激时产生超氧阴离子和释放弹性蛋白酶具有抑制作用。
