Su Li-Hua, Li Yan-Ping, Li Hong-Mei, Dai Wei-Feng, Liu Dan, Cao Lang, Li Rong-Tao
Faculty of Life Science and Technology, Kunming University of Science and Technology.
Chem Pharm Bull (Tokyo). 2016;64(5):497-501. doi: 10.1248/cpb.c15-00661.
Two new [neougonins A (1) and B (2)] and nine known prenylated flavonoids were isolated from the whole plants of Helminthostachys zeylanica. The structures of the new isolates were elucidated by extensive NMR techniques, including one and two dimensional (1D)- and (2D)-NMR experiments, as well as comparison with spectroscopic data of known analogous compounds. Moreover, compound 1 inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with an IC50 value of 3.32 µM.
从七指蕨的全株中分离出两种新的化合物[新七指蕨素A（1）和B（2）]以及九种已知的异戊烯基黄酮类化合物。通过广泛的核磁共振技术，包括一维和二维（1D）-和（2D）-核磁共振实验，以及与已知类似化合物的光谱数据进行比较，阐明了新分离物的结构。此外，化合物1抑制脂多糖（LPS）诱导的RAW264.7细胞中一氧化氮（NO）的产生，IC50值为3.32µM。
