Boyd Lara A, Linsdell Meghan A
Department of Physical Therapy, University of British Columbia, Vancouver, Canada.
BMC Neurosci. 2009 Jul 7;10:72. doi: 10.1186/1471-2202-10-72.
Following practice of skilled movements, changes continue to take place in the brain that both strengthen and modify memory for motor learning. These changes represent motor memory consolidation a process whereby new memories are transformed from a fragile to a more permanent, robust and stable state. In the present study, the neural correlates of motor memory consolidation were probed using repetitive transcranial magnetic stimulation (rTMS) to the dorsal premotor cortex (PMd). Participants engaged in four days of continuous tracking practice that immediately followed either excitatory 5 HZ, inhibitory 1 HZ or control, sham rTMS. A delayed retention test assessed motor learning of repeated and random sequences of continuous movement; no rTMS was applied at retention.
We discovered that 5 HZ excitatory rTMS to PMd stimulated motor memory consolidation as evidenced by off-line learning, whereas only memory stabilization was noted following 1 Hz inhibitory or sham stimulation.
Our data support the hypothesis that PMd is important for continuous motor learning, specifically via off-line consolidation of learned motor behaviors.
在进行熟练运动练习后，大脑中会持续发生变化，这些变化既能强化又能修改运动学习记忆。这些变化代表运动记忆巩固，即新记忆从脆弱状态转变为更持久、稳固和稳定状态的过程。在本研究中，通过对背侧运动前皮层（PMd）进行重复经颅磁刺激（rTMS）来探究运动记忆巩固的神经相关性。参与者进行了为期四天的连续跟踪练习，练习后立即接受5赫兹兴奋性、1赫兹抑制性或对照假rTMS。延迟保留测试评估了连续运动的重复和随机序列的运动学习；在保留测试时未施加rTMS。
我们发现，对PMd施加5赫兹兴奋性rTMS可刺激运动记忆巩固，离线学习证明了这一点，而在1赫兹抑制性或假刺激后仅观察到记忆稳定。
我们的数据支持以下假设，即PMd对连续运动学习很重要，特别是通过对所学运动行为的离线巩固。
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