Mathiesen O, Bonderup O, Carl J, Panduro J, Pedersen K O
Department of Oncology, Alborg Hospital, Denmark.
Acta Oncol. 1991;30(6):691-5. doi: 10.3109/02841869109092441.
In the period from September 1980 to December 1987, our laboratory measured estrogen (ER) and progesterone receptor (PgR) levels in 960 patients with primary breast cancer. At presentation, 918 of these had no distant metastases. ER as well as PgR were considered positive at values above 10 fmol/mg cytosol protein. All the patients included had been operated on at one of two participating hospitals in the country of North Jutland, and all patients had been checked up in a uniform way at one oncological out-patient department. By applying test for interaction, the PgR was found to be dependent on nodal status. Separate multivariate analyses were carried out for node positive and node negative patients. By this method, size of tumor, histologic grading, and age turned out to be independent prognostic factors for the node negative patients. Independent prognostic parameters for the node positive patients were histologic grading, PgR and postoperative x-ray therapy. The results support the theory that PgR is a better predictor of disease-free survival than ER.
在1980年9月至1987年12月期间，我们实验室检测了960例原发性乳腺癌患者的雌激素（ER）和孕激素受体（PgR）水平。就诊时，其中918例无远处转移。当细胞质蛋白中ER及PgR的值高于10 fmol/mg时被视为阳性。纳入的所有患者均在北日德兰半岛该国的两家参与研究的医院之一接受了手术，并且所有患者均在一个肿瘤门诊以统一方式进行了检查。通过应用交互作用检验，发现PgR依赖于淋巴结状态。对淋巴结阳性和阴性患者分别进行了多因素分析。通过这种方法，肿瘤大小、组织学分级和年龄被证明是淋巴结阴性患者的独立预后因素。淋巴结阳性患者的独立预后参数是组织学分级、PgR和术后放疗。结果支持PgR比ER是无病生存更好预测指标的理论。
