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年龄不影响布比卡因的血清蛋白结合率。

Age does not influence the serum protein binding of bupivacaine.

作者信息

Veering B T, Burm A G, Gladines M P, Spierdijk J

机构信息

Department of Anesthesiology, Leiden University Hospital, The Netherlands.

出版信息

Br J Clin Pharmacol. 1991 Oct;32(4):501-3. doi: 10.1111/j.1365-2125.1991.tb03938.x.

DOI:10.1111/j.1365-2125.1991.tb03938.x
PMID:1958446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1368613/
Abstract

The serum protein binding of bupivacaine was studied in 74 subjects, 39 males and 35 females, aged 20-90 years, without evidence of acute or chronic inflammatory disease or malignancy. Subjects were drug free for at least 1 month. The free fractions of bupivacaine did not change with age in either males or females. This is in keeping with the lack of effect of age on AAG concentrations. Free fractions of bupivacaine were slightly higher in females as compared with males. The previously observed decline in clearance of bupivacaine with age probably reflects a concomitant decline in the metabolic activity of hepatic enzymes.

摘要

在74名年龄在20至90岁之间、无急性或慢性炎症性疾病或恶性肿瘤迹象的受试者（39名男性和35名女性）中研究了布比卡因的血清蛋白结合情况。受试者至少1个月未使用药物。布比卡因的游离分数在男性和女性中均不随年龄变化。这与年龄对AAG浓度无影响一致。与男性相比，布比卡因在女性中的游离分数略高。先前观察到的布比卡因清除率随年龄下降可能反映了肝酶代谢活性的相应下降。

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本文引用的文献

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Sex-related differences in the plasma protein binding of lignocaine and diazepam.利多卡因和地西泮血浆蛋白结合的性别差异。
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Gas chromatographic determination of bupivacaine in plasma using a support coated open tubular column and a nitrogen-selective detector.使用涂载体开口管柱和氮选择性检测器通过气相色谱法测定血浆中的布比卡因。
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