利多卡因和地西泮血浆蛋白结合的性别差异。
Sex-related differences in the plasma protein binding of lignocaine and diazepam.
作者信息
Routledge P A, Stargel W W, Kitchell B B, Barchowsky A, Shand D G
出版信息
Br J Clin Pharmacol. 1981 Mar;11(3):245-50. doi: 10.1111/j.1365-2125.1981.tb00528.x.
Abstract
1 The percentage of lignocaine free in the plasma of ten females receiving oral contraceptive medication was significantly greater than in 17 males of similar age (18--42 years). 2 In the same subjects the percentage of diazepam free in plasma was significantly greater in the contraceptive treated group than in 11 contraceptive-free females and significantly greater in contraceptive-free females than in males. 3 The differences in lignocaine binding were almost completely attributable to changes in alpha 1-acid glycoprotein concentration, which is reduced by oestrogens. The binding of diazepam was significantly related to albumin, alpha 1-acid glycoprotein and non-esterified fatty acid concentrations which together were related to 55% of the variation in the binding of this basic compound.
摘要
- 十名服用口服避孕药的女性血浆中游离利多卡因的百分比显著高于17名年龄相仿（18 - 42岁）的男性。2. 在同一批受试者中，接受避孕药治疗组血浆中游离地西泮的百分比显著高于11名未服用避孕药的女性，且未服用避孕药的女性中该百分比显著高于男性。3. 利多卡因结合的差异几乎完全归因于α1 - 酸性糖蛋白浓度的变化，雌激素可使其降低。地西泮的结合与白蛋白、α1 - 酸性糖蛋白和非酯化脂肪酸浓度显著相关，这些因素共同与这种碱性化合物结合的55%的变化相关。
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