Pricolo V E, Potenti F, Soderberg C H
Department of Surgery, Rhode Island Hospital, Providence 02903.
Ann Vasc Surg. 1991 Sep;5(5):462-6. doi: 10.1007/BF02133053.
Different theories have been postulated in the last 10 years in an attempt to explain the pathogenetic mechanisms involved in perigraft seroma formation. This paper reports our experience with in vitro analysis of the cellular composition and the effect of perigraft seroma fluid on fibroblast proliferative activity. Our results indicate that the cellular component of the fluid was almost exclusively represented by polymorphonuclear leukocytes. Perigraft seroma fluid was stimulatory on fibroblast growth, while plasma samples from the patient and normal controls were inhibitory. These findings suggest that a perigraft seroma may represent a complex phenomenon which cannot be explained exclusively in terms of fibroblast stimulation or inhibition. This pattern displays a close similarity to experimental observations in the early phases of wound healing. Perigraft seroma formation could be mediated by an intense and persistent chemotactic stimulus on leukocytes, which does not allow normal progression of wound healing through fibroblast growth and collagen deposition.
在过去十年中，人们提出了不同的理论来试图解释移植物周围血清肿形成所涉及的发病机制。本文报告了我们对移植物周围血清肿液体的细胞组成及其对成纤维细胞增殖活性影响的体外分析经验。我们的结果表明，该液体的细胞成分几乎完全由多形核白细胞构成。移植物周围血清肿液体对成纤维细胞生长具有刺激作用，而患者的血浆样本和正常对照样本则具有抑制作用。这些发现表明，移植物周围血清肿可能是一种复杂的现象，不能仅从成纤维细胞的刺激或抑制方面来解释。这种模式与伤口愈合早期阶段的实验观察结果极为相似。移植物周围血清肿的形成可能是由对白细胞的强烈且持续的趋化刺激所介导的，这使得伤口无法通过成纤维细胞生长和胶原蛋白沉积正常愈合。
