双药从乳液静电纺纳米纤维垫中的控释。

Controlled release of dual drugs from emulsion electrospun nanofibrous mats.

作者信息

Yan Su, Xiaoqiang Li, Shuiping Liu, Xiumei Mo, Ramakrishna Seeram

机构信息

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, China.

出版信息

Colloids Surf B Biointerfaces. 2009 Oct 15;73(2):376-81. doi: 10.1016/j.colsurfb.2009.06.009. Epub 2009 Jun 13.

DOI:10.1016/j.colsurfb.2009.06.009

PMID:19586756

Abstract

The purpose of this work is to develop a novel type of tissue engineering scaffold or drugs delivery carrier with the capability of encapsulation and controlled release drugs. In this study, Rhodamine B and Bovine Serum Albumin (BSA) were successfully incorporated into nanofibers by means of emulsion electrospinning. The morphology of composite nanofibers was studied by Scanning Electron Microscopy (SEM). The composite nanofibrous mats made from emulsion electrospinning were characterized by water contact angle measurement and X-ray diffraction. In vitro dual drugs release behaviors from composite nanofibrous mats were investigated. The results indicated that the incorporated drug and/or proteins in composite fibrous mats made from electrospinning could be control released by adjusting the processes of emulsions preparation.

摘要

这项工作的目的是开发一种新型的组织工程支架或药物递送载体，具有包封和控释药物的能力。在本研究中，通过乳液静电纺丝成功地将罗丹明B和牛血清白蛋白（BSA）掺入纳米纤维中。通过扫描电子显微镜（SEM）研究了复合纳米纤维的形态。通过水接触角测量和X射线衍射对由乳液静电纺丝制成的复合纳米纤维垫进行了表征。研究了复合纳米纤维垫的体外双药释放行为。结果表明，通过调节乳液制备过程，可以控制由静电纺丝制成的复合纤维垫中掺入的药物和/或蛋白质的释放。