Wang Yazhou, Li Zong, Shao Pengyu, Hao Shilei, Wang Wei, Yang Qian, Wang Bochu
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
Mater Sci Eng C Mater Biol Appl. 2014 Nov;44:109-16. doi: 10.1016/j.msec.2014.08.015. Epub 2014 Aug 10.
We have developed a novel drug delivery system with the swelling core for differential release of multiple drugs by emulsion electrospinning, in which the aqueous phase is composed of polyvinyl alcohol and the oil phase consists of poly(ε-caprolactone). The microscopy images indicate that the W/O nanofibers with swelling core structure are successfully prepared and the model drugs, Rhodamine B and bovine serum albumin, were encapsulated in the fibers. In vitro drug release study demonstrated that this core-sheath structure could significantly alleviate the initial drug burst release and provided a differential diffusion pathway to release. It could be found that the postponement of the maximum accumulated release of bovine serum albumin was found due to the presence of sodium citrate and different types of polyvinyl alcohol. This study would provide a basis for optimization of encapsulation conditions to control the release of multiple agents and ultimately be applied in cancer chemotherapy.
我们通过乳液静电纺丝开发了一种具有溶胀核的新型药物递送系统，用于多种药物的差异释放，其中水相由聚乙烯醇组成，油相由聚（ε-己内酯）组成。显微镜图像表明，成功制备了具有溶胀核结构的水包油纳米纤维，模型药物罗丹明B和牛血清白蛋白被包裹在纤维中。体外药物释放研究表明，这种核壳结构可以显著减轻药物的初始突释，并提供差异扩散途径进行释放。可以发现，由于柠檬酸钠和不同类型聚乙烯醇的存在，牛血清白蛋白的最大累积释放被推迟。本研究将为优化包封条件以控制多种药物的释放提供依据，并最终应用于癌症化疗。
