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一个用于可兴奋和振荡神经元的最小生物物理模型。

A minimal biophysical model for an excitable and oscillatory neuron.

作者信息

Av-Ron E, Parnas H, Segel L A

机构信息

Department of Applied Mathematics and Computer Science, Weizmann Institute of Science, Rehovot, Israel.

出版信息

Biol Cybern. 1991;65(6):487-500. doi: 10.1007/BF00204662.

DOI:10.1007/BF00204662
PMID:1958734
Abstract

Presented here is a minimal biophysical cell model, based on work by Hodgkin and Huxley and by Rinzel, that can exhibit both excitable and oscillatory behavior. Two versions of the model are studied, which conform to data for squid and lobster giant axons.

摘要

这里展示的是一个基于霍奇金和赫胥黎以及林泽尔的研究成果的最小生物物理细胞模型,它能够展现出可兴奋行为和振荡行为。我们研究了该模型的两个版本,它们与鱿鱼和龙虾巨轴突的数据相符。

相似文献

1
A minimal biophysical model for an excitable and oscillatory neuron.一个用于可兴奋和振荡神经元的最小生物物理模型。
Biol Cybern. 1991;65(6):487-500. doi: 10.1007/BF00204662.
2
A theoretical study on heat production in squid giant axon.鱿鱼巨大轴突产热的理论研究。
J Theor Biol. 1983 Sep 7;104(1):43-52. doi: 10.1016/0022-5193(83)90400-9.
3
Bifurcation of periodic solutions of Hodgkin-Huxley model for the squid giant axon.乌贼巨大轴突的霍奇金-赫胥黎模型周期解的分岔
J Theor Biol. 1978 Apr 6;71(3):401-20. doi: 10.1016/0022-5193(78)90168-6.
4
Scaling law for the transient behavior of type-II neuron models.II型神经元模型瞬态行为的标度律。
Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Feb;75(2 Pt 1):021911. doi: 10.1103/PhysRevE.75.021911. Epub 2007 Feb 20.
5
[Propagation of the action potential in the vicinity of the soma of giant neurons after the Hodgkin--Huxley model].[基于霍奇金-赫胥黎模型的巨神经元胞体附近动作电位的传播]
Neirofiziologiia. 1975;7(4):422-7.
6
Physical-chemical approach to the transient change in Na ion conductivity of excitable membranes.可兴奋膜钠离子电导率瞬态变化的物理化学方法。
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4492-6. doi: 10.1073/pnas.73.12.4492.
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A proposed membrane model for generation of sodium currents in squid giant axons.一种关于鱿鱼巨轴突中钠电流产生的膜模型设想。
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Effects of channel blocking on information transmission and energy efficiency in squid giant axons.通道阻断对鱿鱼巨轴突中信息传递和能量效率的影响。
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The standard Hodgkin-Huxley model and squid axons in reduced external Ca++ fail to accommodate to slowly rising currents.标准的霍奇金-赫胥黎模型以及外部钙离子浓度降低的鱿鱼轴突无法适应缓慢上升的电流。
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本文引用的文献

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Functional Organization of the Cardiac Ganglion of the Lobster, Homarus americanus.美洲龙虾心脏神经节的功能组织。
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Impulses and Physiological States in Theoretical Models of Nerve Membrane.神经膜理论模型中的冲动与生理状态
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Membrane potentials of the lobster giant axon obtained by use of the sucrose-gap technique.采用蔗糖间隙技术测得的龙虾巨轴突的膜电位。
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CA1 pyramidal cells have diverse biophysical properties, affected by development, experience, and aging.CA1锥体细胞具有多样的生物物理特性,受发育、经验和衰老的影响。
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Mechanisms explaining transitions between tonic and phasic firing in neuronal populations as predicted by a low dimensional firing rate model.由低维发放率模型预测的神经元群体中紧张性和相位性发放之间转换的机制。
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Current-voltage relations in the lobster giant axon membrane under voltage clamp conditions.电压钳制条件下龙虾巨轴突膜的电流-电压关系
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Applicability of Hodgkin-Huxley model to experimental data from the giant axon of lobster.霍奇金-赫胥黎模型对龙虾巨轴突实验数据的适用性。
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Interactions of calcium with sodium and potassium in membrane potentials of the lobster giant axon.龙虾大轴突膜电位中钙与钠和钾的相互作用。
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Effects of external ions on membrane potentials of a lobster giant axon.外部离子对龙虾巨轴突膜电位的影响。
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A quantitative description of membrane current and its application to conduction and excitation in nerve.膜电流的定量描述及其在神经传导和兴奋中的应用。
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