在健康的非肥胖人群中，腹部肥胖与C反应蛋白升高有关，且独立于体重指数。
Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people.
作者信息
Lapice Emanuela, Maione Simona, Patti Lidia, Cipriano Paola, Rivellese Angela A, Riccardi Gabriele, Vaccaro Olga
机构信息
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
出版信息
Diabetes Care. 2009 Sep;32(9):1734-6. doi: 10.2337/dc09-0176. Epub 2009 Jul 8.
OBJECTIVE
There is debate over the most appropriate adiposity markers of obesity-associated health risks. We evaluated the relationship between fat distribution and high-sensitivity C-reactive protein (hs-CRP), independent of total adiposity.
RESEARCH DESIGN AND METHODS
We studied 350 people with abdominal adiposity (waist-to-hip ratio [WHR] > or =0.9 in male and > or =0.85 in female subjects) and 199 control subjects (WHR <0.9 in male and <0.85 in female subjects) matched for BMI and age. We measured hs-CRP and major cardiovascular risk factors.
RESULTS
Participants with abdominal adiposity had BMI similar to that in control subjects (24.8 +/- 2.5 vs. 24.7 +/- 2.2 kg/m(2), respectively), but significantly higher waist circumference (96.4 +/- 6.0 vs. 83.3 +/- 6.7 cm; P < 0.01) and WHR (1.07 +/- 0.08 vs. 0.85 +/- 0.05; P < 0.001). Compared with the control subjects, participants with abdominal adiposity had an adverse cardiovascular risk factor profile, significantly higher hs-CRP (1.96 +/- 2.60 vs. 1.53 +/- 1.74 mg/dl; P < 0.01), and a twofold prevalence of elevated CRP values (>3 mg/dl).
CONCLUSIONS
In nonobese people, moderate abdominal adiposity is associated with markers of subclinical inflammation independent of BMI.
目的
关于肥胖相关健康风险最适宜的肥胖指标存在争议。我们评估了脂肪分布与高敏C反应蛋白（hs-CRP）之间的关系，且不考虑总体肥胖情况。
研究设计与方法
我们研究了350例腹部肥胖者（男性腰臀比[WHR]≥0.9，女性≥0.85）以及199例对照者（男性WHR<0.9，女性<0.85），这些对照者在体重指数（BMI）和年龄方面与腹部肥胖者相匹配。我们测量了hs-CRP及主要心血管危险因素。
结果
腹部肥胖参与者的BMI与对照者相似（分别为24.8±2.5和24.7±2.2kg/m²），但腰围显著更高（96.4±6.0对83.3±6.7cm；P<0.01），WHR也显著更高（1.07±0.08对0.85±0.05；P<0.001）。与对照者相比，腹部肥胖参与者具有不良的心血管危险因素谱，hs-CRP显著更高（1.96±2.60对1.53±1.74mg/dl；P<0.01），且CRP值升高（>3mg/dl）的患病率为对照者的两倍。
结论
在非肥胖人群中，中度腹部肥胖与亚临床炎症指标相关，且独立于BMI。
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