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General and abdominal adiposity and risk of death in Europe.欧洲的总体及腹部肥胖与死亡风险
N Engl J Med. 2008 Nov 13;359(20):2105-20. doi: 10.1056/NEJMoa0801891.
2
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.瑞舒伐他汀预防C反应蛋白升高的男性和女性发生血管事件。
N Engl J Med. 2008 Nov 20;359(21):2195-207. doi: 10.1056/NEJMoa0807646. Epub 2008 Nov 9.
3
C-reactive protein and coronary heart disease: a critical review.C反应蛋白与冠心病：批判性综述
J Intern Med. 2008 Oct;264(4):295-314. doi: 10.1111/j.1365-2796.2008.02015.x.
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BMI vs. waist circumference for identifying vascular risk.用于识别血管风险的体重指数与腰围对比
Obesity (Silver Spring). 2008 Feb;16(2):463-9. doi: 10.1038/oby.2007.75.
5
Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study.内脏和皮下脂肪组织体积与炎症和氧化应激标志物存在横断面相关性：弗雷明汉心脏研究。
Circulation. 2007 Sep 11;116(11):1234-41. doi: 10.1161/CIRCULATIONAHA.107.710509. Epub 2007 Aug 20.
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Inflammatory markers and the risk of coronary heart disease in men and women.炎症标志物与男性和女性冠心病风险
N Engl J Med. 2004 Dec 16;351(25):2599-610. doi: 10.1056/NEJMoa040967.
7
Relationship of total and abdominal adiposity with CRP and IL-6 in women.女性总体及腹部肥胖与C反应蛋白和白细胞介素-6的关系。
Ann Epidemiol. 2003 Nov;13(10):674-82. doi: 10.1016/s1047-2797(03)00053-x.
8
C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women.C反应蛋白与成年女性的全身脂肪、中心性脂肪及胰岛素抵抗独立相关。
Int J Obes Relat Metab Disord. 2001 Oct;25(10):1416-20. doi: 10.1038/sj.ijo.0801719.
9
The relation of body fat mass and distribution to markers of chronic inflammation.体脂量及分布与慢性炎症标志物的关系。
Int J Obes Relat Metab Disord. 2001 Oct;25(10):1407-15. doi: 10.1038/sj.ijo.0801792.
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Plasma fibrinogen: a new factor of the metabolic syndrome. A population-based study.血浆纤维蛋白原：代谢综合征的一个新因素。一项基于人群的研究。
Diabetes Care. 1998 Apr;21(4):649-54. doi: 10.2337/diacare.21.4.649.

在健康的非肥胖人群中，腹部肥胖与C反应蛋白升高有关，且独立于体重指数。

Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people.

作者信息

Lapice Emanuela, Maione Simona, Patti Lidia, Cipriano Paola, Rivellese Angela A, Riccardi Gabriele, Vaccaro Olga

机构信息

Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.

出版信息

Diabetes Care. 2009 Sep;32(9):1734-6. doi: 10.2337/dc09-0176. Epub 2009 Jul 8.

DOI:10.2337/dc09-0176
PMID:19587368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2732149/
Abstract

OBJECTIVE

There is debate over the most appropriate adiposity markers of obesity-associated health risks. We evaluated the relationship between fat distribution and high-sensitivity C-reactive protein (hs-CRP), independent of total adiposity.

RESEARCH DESIGN AND METHODS

We studied 350 people with abdominal adiposity (waist-to-hip ratio [WHR] > or =0.9 in male and > or =0.85 in female subjects) and 199 control subjects (WHR <0.9 in male and <0.85 in female subjects) matched for BMI and age. We measured hs-CRP and major cardiovascular risk factors.

RESULTS

Participants with abdominal adiposity had BMI similar to that in control subjects (24.8 +/- 2.5 vs. 24.7 +/- 2.2 kg/m(2), respectively), but significantly higher waist circumference (96.4 +/- 6.0 vs. 83.3 +/- 6.7 cm; P < 0.01) and WHR (1.07 +/- 0.08 vs. 0.85 +/- 0.05; P < 0.001). Compared with the control subjects, participants with abdominal adiposity had an adverse cardiovascular risk factor profile, significantly higher hs-CRP (1.96 +/- 2.60 vs. 1.53 +/- 1.74 mg/dl; P < 0.01), and a twofold prevalence of elevated CRP values (>3 mg/dl).

CONCLUSIONS

In nonobese people, moderate abdominal adiposity is associated with markers of subclinical inflammation independent of BMI.

摘要

目的

关于肥胖相关健康风险最适宜的肥胖指标存在争议。我们评估了脂肪分布与高敏C反应蛋白（hs-CRP）之间的关系，且不考虑总体肥胖情况。

研究设计与方法

我们研究了350例腹部肥胖者（男性腰臀比[WHR]≥0.9，女性≥0.85）以及199例对照者（男性WHR<0.9，女性<0.85），这些对照者在体重指数（BMI）和年龄方面与腹部肥胖者相匹配。我们测量了hs-CRP及主要心血管危险因素。

结果

腹部肥胖参与者的BMI与对照者相似（分别为24.8±2.5和24.7±2.2kg/m²），但腰围显著更高（96.4±6.0对83.3±6.7cm；P<0.01），WHR也显著更高（1.07±0.08对0.85±0.05；P<0.001）。与对照者相比，腹部肥胖参与者具有不良的心血管危险因素谱，hs-CRP显著更高（1.96±2.60对1.53±1.74mg/dl；P<0.01），且CRP值升高（>3mg/dl）的患病率为对照者的两倍。

结论

在非肥胖人群中，中度腹部肥胖与亚临床炎症指标相关，且独立于BMI。