Du Guang, Ma Baoxia, Zhang Rui, Sun Minghui
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
J Huazhong Univ Sci Technolog Med Sci. 2002;22(3):221-3. doi: 10.1007/BF02828185.
In order to study the modulatory effects of compound polysaccharide Erweikang on the immune function of the immunosuppressive mice, the positive immune modulation of Erweikang at different doses and different time points was compared when normal saline and cyclophosphamide served as controls. The results showed that different doses of Erweikang could effectively reverse the decreased induction levels of NK, IL-2, gamma-IFN and the contents of TNF and IgF of the immunosuppressive mice after administration of Erweikang for 7 to 14 days. It was suggested that compound polysaccharide Erweikang presents positive immune modulation in dose- and time-dependent manners.
为研究复方多糖二味康对免疫抑制小鼠免疫功能的调节作用，以生理盐水和环磷酰胺为对照，比较不同剂量二味康在不同时间点的阳性免疫调节作用。结果显示，给予二味康7至14天后，不同剂量的二味康能有效逆转免疫抑制小鼠NK、IL-2、γ-干扰素的诱导水平降低以及TNF和IgF含量降低的情况。提示复方多糖二味康呈现出剂量和时间依赖性的阳性免疫调节作用。
