Kozuma S, Nemoto A, Okai T, Mizuno M
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
Biol Neonate. 1991;60 Suppl 1:36-40. doi: 10.1159/000251015.
The inspiratory times of fetal breathing movements were measured in REM and NREM periods, respectively, and their changes with advancing gestational age were investigated. Ten women without complications in their 20th to 40th week of pregnancy were examined. Fetal breathing movements and REM were observed simultaneously using ultrasonography. REM and NREM periods were selected for analyzing breathing movements separate from the whole examination period. The inspiratory times of fetal breathing movements were measured with the hand-held pressure transducer. The changes in inspiratory time with fetal age showed the same pattern both in REM and NREM periods. There were no significant changes in inspiratory time before 28 weeks gestational age. After that, the inspiratory time lengthened, showing the maximum at 32-35 weeks and then shortened at 36-40 weeks gestational age. There were no differences of the inspiratory time between REM and NREM periods before 32 weeks. After 32 weeks, the inspiratory time in the NREM period was longer than in the REM period. These changes in fetal breathing movements are thought to be caused by the morphological maturation of the fetal lung and the functional development of respiratory and sleep center of the fetal central nervous system.
分别在快速眼动（REM）期和非快速眼动（NREM）期测量胎儿呼吸运动的吸气时间，并研究其随孕周增加的变化。对10名妊娠20至40周无并发症的女性进行了检查。使用超声同时观察胎儿呼吸运动和快速眼动。从整个检查期挑选出快速眼动期和非快速眼动期来分析呼吸运动。用手持式压力传感器测量胎儿呼吸运动的吸气时间。胎儿呼吸运动吸气时间随胎龄的变化在快速眼动期和非快速眼动期均呈现相同模式。孕28周前吸气时间无显著变化。此后，吸气时间延长，在孕32 - 35周时达到最长，然后在孕36 - 40周时缩短。孕32周前快速眼动期和非快速眼动期的吸气时间无差异。孕32周后，非快速眼动期的吸气时间比快速眼动期长。胎儿呼吸运动的这些变化被认为是由胎儿肺的形态成熟以及胎儿中枢神经系统呼吸和睡眠中枢的功能发育引起的。
