Aou S, Takaki A, Karádi Z, Hori T, Nishino H, Oomura Y
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Brain Res Bull. 1991 Sep-Oct;27(3-4):451-5. doi: 10.1016/0361-9230(91)90141-6.
Regional differences in the effects of electrical (ES) and chemical stimulation on execution of a bar-press feeding task, and in neuronal activity related to feeding, glucose sensitivity, and odor responsiveness were examined in the lateral hypothalamic area (LHA) of monkeys. In satiated animals, ES of the far lateral and ventral LHA induced bar-press feeding. In hungry animals, ES of the dorsal LHA suppressed the feeding task only during the stimulation period, but prolonged feeding suppression that occurred after ES of the ventromedial LHA. Microinjection of Na-glutamate into LHA sites where ES was effective in suppressing feeding had no effect, but it was effective in the medial hypothalamus. Glucose-sensitive (GS) neurons decreased in activity during bar pressing and/or during the ingestion period. Glucose-insensitive (GIS) neurons showed a cue-related excitation more often than GS neurons. Odor-responding GS and GIS cells were localized in ventromedial and lateral LHA sites, respectively. The present study suggests the regional heterogeneity of the LHA in feeding regulation, depending on both hunger and satiety states.
研究了电刺激（ES）和化学刺激对猴子在压杆进食任务执行中的影响，以及与进食、葡萄糖敏感性和气味反应相关的神经元活动在外侧下丘脑区域（LHA）的区域差异。在饱腹动物中，最外侧和腹侧LHA的电刺激诱导了压杆进食。在饥饿动物中，背侧LHA的电刺激仅在刺激期间抑制进食任务，但延长了腹内侧LHA电刺激后出现的进食抑制。向LHA中电刺激有效抑制进食的部位微量注射谷氨酸钠没有效果，但在内侧下丘脑有效。葡萄糖敏感（GS）神经元在压杆和/或摄食期间活动减少。葡萄糖不敏感（GIS）神经元比GS神经元更常表现出与线索相关的兴奋。对气味有反应的GS和GIS细胞分别位于腹内侧和外侧LHA部位。本研究表明，LHA在进食调节方面存在区域异质性，这取决于饥饿和饱腹状态。
