Department of Health and Human Performance, Laboratory of Integrated Physiology, University of Houston, Houston, TX 77204-6015, USA.
J Pediatr Gastroenterol Nutr. 2009 Oct;49(4):450-5. doi: 10.1097/MPG.0b013e31819bc91e.
Excess adiposity is associated with systemic low-grade inflammation, which has been implicated in the pathophysiology of various diseases. The purpose of this study was to examine the relation between measures of adiposity and disease risk factors in Mexican American children participating in a weight loss intervention.
Boys and girls (N=170; 13.3+/-0.1 year) volunteered for additional testing from a larger study that demonstrated significant reduction in standardized body mass index. Insulin, C-reactive protein, soluble cluster of differentiation 14, glucose, and cholesterol profile were assessed.
Linear mixed models regression showed that changes in adiposity (standardized body mass index and triceps skinfold) were significantly related with changes in total cholesterol (P=0.01), triglycerides (P<0.001), C-reactive protein (P<0.001), insulin (P<0.001), Homeostasis model assessment of insulin resistance (P<0.001), and high-density lipoprotein (P<0.001).
The relation between measures of adiposity and disease risk factors was stable over time in children participating in an exercise/weight loss intervention. Also, our findings indicate that reducing adiposity results in an improvement of blood disease risk factors in Mexican American children.
肥胖与全身性低度炎症有关，后者与多种疾病的病理生理学有关。本研究的目的是检验参与减肥干预的墨西哥裔美国儿童的肥胖测量值与疾病风险因素之间的关系。
男孩和女孩（N=170；13.3±0.1 岁）自愿参加一项更大规模的研究，该研究表明标准化体重指数显著降低。评估了胰岛素、C 反应蛋白、可溶性分化簇 14、葡萄糖和胆固醇谱。
线性混合模型回归显示，体脂变化（标准化体重指数和三头肌皮褶）与总胆固醇（P=0.01）、甘油三酯（P<0.001）、C 反应蛋白（P<0.001）、胰岛素（P<0.001）、胰岛素稳态模型评估（P<0.001）和高密度脂蛋白（P<0.001）的变化显著相关。
在参加运动/减肥干预的儿童中，肥胖测量值与疾病风险因素之间的关系是稳定的。此外，我们的研究结果表明，降低肥胖可改善墨西哥裔美国儿童的血液疾病风险因素。
