MMWR Morb Mortal Wkly Rep. 2009 Jul 10;58(26):716-9.
CDC recommends screening of at-risk men who have sex with men (MSM) at least annually for urethral and rectal gonorrhea and chlamydia, and for pharyngeal gonorrhea. Although the standard method for diagnosis is culture, nucleic acid amplification (NAA) testing is generally more sensitive and favored by most experts. NAA tests have not been cleared by the Food and Drug Administration (FDA) for the diagnosis of extragenital chlamydia or gonorrhea and may not be marketed for that purpose. However, under U.S. law, laboratories may offer NAA testing for diagnosis of extragenital chlamydia or gonorrhea after internal validation of the method by a verification study. To determine sexually transmitted disease (STD) testing practices among community-based organizations serving MSM, CDC and the San Francisco Department of Public Health gathered data on rectal and pharyngeal gonorrhea and chlamydia testing at screening sites managed by six gay-focused community-based organizations in five U.S. cities during 2007. This report summarizes the results of the study, which found that three organizations collected samples for NAA testing and three for culture. In total, approximately 30,000 tests were performed; 5.4% of rectal gonorrhea, 8.9% of rectal chlamydia, 5.3% of pharyngeal gonorrhea, and 1.6% of pharyngeal chlamydia tests were positive. These results demonstrate that gay-focused community-based organizations can detect large numbers of gonorrhea and chlamydia cases and might reach MSM not being tested elsewhere. Public health officials could consider providing support to certain community-based organizations to facilitate testing and treatment of gonorrhea and chlamydia.
美国疾病控制与预防中心(CDC)建议,与男性发生性行为的高危男性(MSM)至少每年接受一次尿道和直肠淋病及衣原体检测,以及咽部淋病检测。虽然诊断的标准方法是培养,但核酸扩增(NAA)检测通常更敏感,且受到大多数专家的青睐。NAA检测尚未获得美国食品药品监督管理局(FDA)批准用于诊断生殖器外衣原体或淋病,不得用于此目的进行销售。然而,根据美国法律,实验室在通过验证研究对方法进行内部验证后,可提供NAA检测用于诊断生殖器外衣原体或淋病。为了确定为男男性行为者提供服务的社区组织中的性传播疾病(STD)检测做法,CDC和旧金山公共卫生部收集了2007年期间美国五个城市六个以同性恋为重点的社区组织管理的筛查点的直肠和咽部淋病及衣原体检测数据。本报告总结了该研究的结果,发现三个组织采集样本进行NAA检测,三个组织进行培养检测。总共进行了约30,000次检测;直肠淋病检测的阳性率为5.4%,直肠衣原体检测为8.9%,咽部淋病检测为5.3%,咽部衣原体检测为1.6%。这些结果表明,以同性恋为重点的社区组织能够检测出大量淋病和衣原体病例,可能接触到在其他地方未接受检测的男男性行为者。公共卫生官员可考虑向某些社区组织提供支持,以促进淋病和衣原体的检测与治疗。