Mert Tufan, Gunay Ismail, Ocal Isil
Faculty of Medicine, Department of Biophysics, Cukurova University, Balcali, Adana, Turkey.
Bioelectromagnetics. 2010 Jan;31(1):39-47. doi: 10.1002/bem.20524.
In the clinic, although several pharmacological agents or surgical procedures are used to treat diabetes and diabetes-induced neuropathic pain, their success has been limited. Therefore, development of different alternatives in treatments is very important. The purpose of this study was to determine the efficacy of pulsed magnetic field (PMF) in improving signs and symptoms of diabetic neuropathy. In this study, the effects of PMF treatment were investigated in Streptozotocin (STZ)-induced acute and chronic diabetic rats by measuring the thermal latencies, mechanical thresholds, whole blood glucose levels and body weights. After STZ administration to rats, blood glucose level elevated and body weight decreased. Although PMF treatment did not affect changes in body weight, the blood glucose levels of PMF-treated diabetic rats exhibited a decrease during the treatments. Diabetic animals displayed marked decrease in mechanical thresholds and thermal latencies. While treatment of PMF partially restored the mechanical thresholds and thermal latency in acute diabetic rats, PMF caused a corrective effect on only mechanical threshold of chronic diabetic rats. These results suggested that treatment of PMF can potentially ameliorate the painful symptoms of diabetes, such as hyperalgesia and allodynia, by partially preventing the hyperglycemia.
在临床上，尽管有几种药物制剂或外科手术用于治疗糖尿病及糖尿病引发的神经性疼痛，但它们的效果有限。因此，开发不同的治疗方案非常重要。本研究的目的是确定脉冲磁场（PMF）在改善糖尿病神经病变体征和症状方面的疗效。在本研究中，通过测量热潜伏期、机械阈值、全血葡萄糖水平和体重，研究了PMF治疗对链脲佐菌素（STZ）诱导的急性和慢性糖尿病大鼠的影响。给大鼠注射STZ后，血糖水平升高，体重下降。尽管PMF治疗不影响体重变化，但接受PMF治疗的糖尿病大鼠的血糖水平在治疗期间有所下降。糖尿病动物的机械阈值和热潜伏期显著降低。虽然PMF治疗可部分恢复急性糖尿病大鼠的机械阈值和热潜伏期，但PMF仅对慢性糖尿病大鼠的机械阈值产生矫正作用。这些结果表明，PMF治疗可能通过部分预防高血糖来改善糖尿病的疼痛症状，如痛觉过敏和异常性疼痛。
