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苗勒管异常:当前治疗方法综述

Müllerian duct anomalies: review of current management.

作者信息

Ribeiro Sérgio Conti, Tormena Renata Assef, Peterson Thais Villela, Gonzáles Marina de Oliveira, Serrano Priscila Gonçalves, Almeida José Alcione Macedo de, Baracat Edmund Chada

机构信息

Department of Gynecology and Obstetrics, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

出版信息

Sao Paulo Med J. 2009 May;127(2):92-6. doi: 10.1590/s1516-31802009000200007.

DOI:10.1590/s1516-31802009000200007
PMID:19597684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10964807/
Abstract

The aim of this paper was to discuss the embryological aspects of Müllerian duct anomalies and to analyze the current diagnostic methods and therapy. Müllerian anomalies are congenital defects of the female reproductive tract resulting from failure in the development of the Müllerian ducts and their associated structures. Their cause has yet to be fully clarified, and it is currently believed to be multifactorial. Symptoms appear principally during adolescence or early adulthood, and affect the reproductive capacity of these women. When clinically suspected, investigations leading to diagnosis include imaging methods such as hysterosalpingography, ultrasonography and magnetic resonance. The classification of these malformations relates to their embryogenesis, and defines the therapy and prognosis. Müllerian anomalies consist of a wide range of defects that may vary from patient to patient. Therefore, their management must also be individual, taking anatomical and clinical characteristics into consideration, as well as the patient's wishes.

摘要

本文旨在探讨苗勒管异常的胚胎学方面,并分析当前的诊断方法和治疗方法。苗勒管异常是女性生殖道的先天性缺陷,由苗勒管及其相关结构发育失败引起。其病因尚未完全阐明,目前认为是多因素的。症状主要出现在青春期或成年早期,并影响这些女性的生殖能力。临床怀疑时,诊断性检查包括子宫输卵管造影、超声检查和磁共振成像等影像学方法。这些畸形的分类与它们的胚胎发生有关,并决定治疗方法和预后。苗勒管异常包括广泛的缺陷,不同患者之间可能有所不同。因此,其治疗也必须个体化,要考虑解剖和临床特征以及患者的意愿。

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Currarino triad with Müllerian duct anomaly in mother and daughter without MNX1 gene mutation.母女患柯拉里诺三联征合并苗勒管异常且无MNX1基因突变
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本文引用的文献

1
Vertical transmission of a mutation in exon 1 of the WT1 gene: lessons for genetic counseling.WT1基因第1外显子突变的垂直传播:遗传咨询的经验教训
Am J Med Genet A. 2008 Sep 15;146A(18):2332-6. doi: 10.1002/ajmg.a.32330.
2
Small-diameter hysteroscopy with Versapoint versus resectoscopy with a unipolar knife for the treatment of septate uterus: a prospective randomized study.使用Versapoint进行小直径宫腔镜检查与使用单极刀进行电切镜检查治疗纵隔子宫的前瞻性随机研究。
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3
Reproductive performance of women with müllerian anomalies.苗勒管异常女性的生殖性能
Curr Opin Obstet Gynecol. 2007 Jun;19(3):229-37. doi: 10.1097/GCO.0b013e32814b0649.
4
Diagnosis of Mullerian anomalies in adults: evaluation of practice.成人苗勒管异常的诊断:实践评估
Fertil Steril. 2008 Jan;89(1):219-22. doi: 10.1016/j.fertnstert.2007.02.044. Epub 2007 May 4.
5
Gene expression change in the Müllerian duct of the mouse fetus exposed to diethylstilbestrol in utero.子宫内暴露于己烯雌酚的小鼠胎儿苗勒管中的基因表达变化。
Exp Biol Med (Maywood). 2007 Apr;232(4):503-14.
6
Septums and synechiae: approaches to surgical correction.鼻中隔和粘连:手术矫正方法
Clin Obstet Gynecol. 2006 Dec;49(4):767-88. doi: 10.1097/01.grf.0000211948.36465.a6.
7
Hysteroscopic metroplasty of the complete uterine septum, duplicate cervix, and vaginal septum.完全性子宫纵隔、双宫颈及阴道纵隔的宫腔镜子宫成形术。
Fertil Steril. 2006 May;85(5):1473-7. doi: 10.1016/j.fertnstert.2005.10.044. Epub 2006 Apr 5.
8
Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina).HOXA7至HOXA13基因及PBX1基因在各种类型的MRKH综合征(先天性子宫和阴道缺失)中的作用
J Negat Results Biomed. 2006 Mar 23;5:4. doi: 10.1186/1477-5751-5-4.
9
Is hysterosalpingography able to diagnose all uterine malformations correctly? A retrospective study.子宫输卵管造影术能否正确诊断所有子宫畸形?一项回顾性研究。
Eur J Radiol. 2005 Feb;53(2):274-9. doi: 10.1016/j.ejrad.2004.04.004.
10
Imaging diagnosis of congenital uterine malformation.先天性子宫畸形的影像学诊断
Comput Med Imaging Graph. 2004 Oct;28(7):425-33. doi: 10.1016/j.compmedimag.2004.05.008.