人工氧载体作为临床实践中红细胞的一种可能替代物。
Artificial oxygen carriers as a possible alternative to red cells in clinical practice.
作者信息
Barbosa Fabiano Timbó, Jucá Mário Jorge, Castro Aldemar Araujo, Duarte José Lira, Barbosa Luciano Timbó
机构信息
Department of Clinical Surgery, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.
出版信息
Sao Paulo Med J. 2009 May;127(2):97-100. doi: 10.1590/s1516-31802009000200008.
Fluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hemoglobin are attractive alternatives to allogenic red blood cells. There are many risks involved in allogenic blood transfusions and they include transmission of infections, delayed postoperative wound healing, transfusion reactions, immunomodulation and cancer recurrence. Regardless of whether artificial oxygen carriers are available for routine clinical use, further studies are needed in order to show the safety and efficacy of these substances for clinical practice.
液体复苏旨在消除微循环障碍并恢复足够的组织氧合。限制性输血策略的安全限度由患者对急性正常血容量性贫血的个体耐受性决定。基于全氟化碳或血红蛋白的人工氧载体是同种异体红细胞有吸引力的替代品。同种异体输血存在许多风险，包括感染传播、术后伤口愈合延迟、输血反应、免疫调节和癌症复发。无论人工氧载体是否可用于常规临床应用，都需要进一步研究以证明这些物质在临床实践中的安全性和有效性。
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