Ningbo University School of Medicine, 315211, Ningbo, China.
Med Oncol. 2010 Sep;27(3):685-9. doi: 10.1007/s12032-009-9269-x. Epub 2009 Jul 14.
MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.
MicroRNAs (miRNAs) 是一类非编码 RNA，可以调控靶 mRNA 的表达。已有报道称，在多种肿瘤类型中存在特定 miRNAs 的表达异常。然而，miR-31 在胃癌中的表达水平尚不清楚。本研究旨在比较胃癌组织和非肿瘤组织中 miR-31 的表达谱。采用实时定量反转录聚合酶链反应技术检测 miR-31 的表达水平。结果发现，胃癌组织中 miR-31 的表达水平明显低于非肿瘤组织。这一新信息可能有助于阐明胃癌发生发展中的分子机制，并提示 miR-31 可能是一种新型胃癌诊断生物标志物。
