男性同性恋者中的自身抗体与HIV感染。

Autoantibodies in male homosexuals and HIV infection.

作者信息

Argov S, Schattner A, Burstein R, Handzel Z T, Shoenfeld Y, Bentwich Z

机构信息

Unit for Autoimmune Diseases, Ben-Gurion University, Beer-Sheba, Israel.

出版信息

Immunol Lett. 1991 Sep;30(1):31-5. doi: 10.1016/0165-2478(91)90086-p.

DOI:10.1016/0165-2478(91)90086-p

PMID:1959941

Abstract

We have used ELISA to study the frequency of autoantibodies to several antigens in the serum of 17 male homosexuals (MHS) negative for HIV (HIV-), 11 asymptomatic HIV seropositive MHS (HIV+) and patients with ARC (N = 15) or AIDS (N = 13), and compared them to 20 matched healthy heterosexual controls. Serum antibody binding to histones, cardiolipin, ss-A, ss-B and Sm was found to be significantly higher in each of the MHS groups studied as compared to controls (P less than 0.001), and was also increased in the HIV+ patients vs. the HIV- group (P less than 0.05). In contrast, no increase in autoantibodies to ss-DNA, ds-DNA, poly(I), poly(G) or RNP were found in any of the groups tested. These results enlarge the spectrum of autoimmunity previously reported in HIV infection and identify a similar pattern to a lesser degree, already present in HIV- MHS, suggesting a role for HIV or concomitant virus infections in its pathogenesis.

摘要

我们采用酶联免疫吸附测定法（ELISA）研究了17名HIV阴性（HIV-）的男性同性恋者（MHS）、11名无症状的HIV血清阳性MHS（HIV+）以及患艾滋病相关综合征（ARC，n = 15）或艾滋病（AIDS，n = 13）患者血清中针对几种抗原的自身抗体频率，并将其与20名匹配的健康异性恋对照者进行比较。结果发现，与对照组相比，各研究的MHS组中血清抗体与组蛋白、心磷脂、ss-A、ss-B和Sm的结合显著更高（P < 0.001），且HIV+患者相对于HIV-组也有所增加（P < 0.05）。相比之下，在任何测试组中均未发现针对ss-DNA、ds-DNA、聚肌苷酸、聚鸟苷酸或核糖核蛋白的自身抗体增加。这些结果拓宽了先前报道的HIV感染中自身免疫的范围，并在较低程度上确定了一种类似模式，这种模式在HIV-的MHS中已然存在，提示HIV或伴随的病毒感染在其发病机制中发挥作用。