Murayama H, Takahara Y, Nakada I, Sudo Y, Sezaki T, Nakamura T
Department of Cardiovascular Surgery, Turumai Hospital, Ichihara, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1991 Sep;39(9):1803-8.
A 60-year-old female with mitral stenosis developed prosthetic valve endocarditis due to methicillin resistant staphylococcus aureus septicemia 3 weeks after mitral valve replacement. In vitro test disclosed susceptibility to minocycline and clindamycin. Despite large amount of intravenous administration, progressive heart failure due to massive perivalvular leakage occurred as a consequence of persisting infection. An emergent operation revealed valve detachment of the posterior portion resulting from ring abscess formation. A mitral prosthesis with a Gore-Tex flange was implanted partially in the left atrium just above the mitral ring and sutured to the atrial wall. Postoperative relapse was not detected even after discontinuing antibiotics. Prosthetic valve endocarditis due to methicillin resistant staphylococcus aureus is highly resistant to antibiotic therapy and likely to develop valve ring abscess. Prompt surgical treatment is mandatory in this situation.
一名60岁女性,患有二尖瓣狭窄,在二尖瓣置换术后3周因耐甲氧西林金黄色葡萄球菌败血症发生人工瓣膜心内膜炎。体外试验显示对米诺环素和克林霉素敏感。尽管大量静脉给药,但由于持续感染,因大量瓣周漏导致进行性心力衰竭。急诊手术发现后叶瓣膜因环形脓肿形成而脱离。一个带有戈尔-tex(戈尔特斯)凸缘的二尖瓣假体部分植入二尖瓣环上方的左心房并缝合至心房壁。即使停用抗生素后也未检测到术后复发。耐甲氧西林金黄色葡萄球菌引起的人工瓣膜心内膜炎对抗生素治疗高度耐药,且很可能发生瓣膜环脓肿。在这种情况下,必须迅速进行手术治疗。