Bostwick D G, Roth K A, Evans C J, Barchas J D, Bensch K G
Am J Pathol. 1984 Nov;117(2):195-200.
Several reports have indicated that the amphibian peptide bombesin is present in oat-cell carcinoma of the human lung. The recent observation that gastrin-releasing peptide (GRP), a 27-amino acid peptide isolated from porcine intestine, may be the mammalian analog of bombesin led the authors to look for this peptide in human pulmonary tumors. Examination of 36 human lung tumors (8 carcinoids, 8 oat-cell carcinomas, and 20 non-oat-cell carcinomas) by immunohistochemistry and radioimmunoassay demonstrated the presence of high, although variable, levels of GRP in neuroendocrine tumors, and not in other histologic types. These findings indicate that bombesin immunoreactivity in human lung tumors should be attributed to GRP or GRP-like molecules and that GRP may be a useful marker of neuroendocrine differentiation.
几份报告指出，两栖类肽蛙皮素存在于人类肺燕麦细胞癌中。最近的观察发现，从猪肠道中分离出的一种27个氨基酸的肽——胃泌素释放肽（GRP），可能是蛙皮素的哺乳动物类似物，这促使作者在人类肺部肿瘤中寻找这种肽。通过免疫组织化学和放射免疫分析对36例人类肺部肿瘤（8例类癌、8例燕麦细胞癌和20例非燕麦细胞癌）进行检测，结果表明神经内分泌肿瘤中存在高水平（尽管存在差异）的GRP，而其他组织学类型中则不存在。这些发现表明，人类肺部肿瘤中的蛙皮素免疫反应性应归因于GRP或GRP样分子，并且GRP可能是神经内分泌分化的有用标志物。
