Department of Textiles, Clothing and Design, University of Nebraska-Lincoln, Lincoln, NE 68583-0802, USA.
J Mater Sci Mater Med. 2009 Dec;20(12):2477-86. doi: 10.1007/s10856-009-3821-2.
Drug release in phosphate buffered saline (PBS pH 7.4) and artificial gastric juice (AGJ pH 1.2) and its relationship with kinetic and thermodynamic parameters of drug sorption onto soy protein (SP) fibers have been studied using Diclofenac, 5 Fluorouracil and Metformin as model drugs. Since SP is biodegradable, biocompatible, abundant and annually renewable, it has been widely used in medical applications. To understand drug release from SP fibers using sorption, kinetic and thermodynamic parameters have been investigated. Quantitative relationship between drug release and drug loading concentration, affinity, and activation energy for diffusion was established to predict initial bursts and later drug release. The study showed that Diclofenac had high initial bursts in PBS but more constant release in AGJ. It also has been found that drugs with lower diffusion coefficient and higher affinity (especially van der Waals force) on SP fiber are more suitable for sorption loading to achieve higher loading capacity and more constant releasing rate.
已经研究了在磷酸盐缓冲盐水（PBS pH 7.4）和人工胃液（AGJ pH 1.2）中的药物释放及其与药物吸附到大豆蛋白（SP）纤维的动力学和热力学参数之间的关系，使用双氯芬酸、5-氟尿嘧啶和二甲双胍作为模型药物。由于 SP 是可生物降解、生物相容、丰富且每年可再生的，因此它已被广泛应用于医疗应用中。为了通过吸附了解 SP 纤维中的药物释放，已经研究了动力学和热力学参数。已经建立了药物释放与药物负载浓度、亲和力和扩散活化能之间的定量关系，以预测初始突释和随后的药物释放。该研究表明，双氯芬酸在 PBS 中具有较高的初始突释，但在 AGJ 中释放更稳定。还发现，在 SP 纤维上具有较低扩散系数和更高亲和力（尤其是范德华力）的药物更适合吸附负载，以实现更高的负载能力和更稳定的释放速率。
