所选有机硫化合物对黑色素形成的影响。
Effects of selected organo-sulfur compounds on melanin formation.
作者信息
Chu Heuy-Ling, Wang Bor-Sen, Duh Pin-Der
机构信息
Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Pao-An, Jen-Te Hsing, Tainan, Taiwan, Republic of China.
出版信息
J Agric Food Chem. 2009 Aug 12;57(15):7072-7. doi: 10.1021/jf9005824.
The effect of organo-sulfur compounds, including 1-propylmercaptan (PM), dimethyl disulfide (DMDS), diallyl disulfide (DADS), propyl disulfide (PDS), and 2,5-dimethylthiophene (DMT), on melanin formation was investigated. Among the selected five organo-sulfur compounds, PM displayed a significant inhibitory effect on tyrosinase activity (IC(50) = 0.5 mM) and the highest inhibitory action on o-quinone formation. In the B16 intracellular model system, the inhibitory action of selected five organo-sulfur compounds on tyrosinase activity and melanin formation may be, in part, attributed to the reduction of the reactive oxygen species (ROS) formation and positive modulation of the GSH/GSSG ratio in B16 cells. Among the five organo-sulfur compounds, PM appeared to be the most potent inhibitor of melanin formation. The analysis of inhibitory kinetics revealed that PM is a mixed-type inhibitor. This is the first study indicating that organo-sulfur compounds tested may play an important role in the regulation of melanin formation, making them the potent candidates for skin-whitening agents.
研究了包括1-丙硫醇（PM）、二甲基二硫醚（DMDS）、二烯丙基二硫醚（DADS）、丙基二硫醚（PDS）和2,5-二甲基噻吩（DMT）在内的有机硫化合物对黑色素形成的影响。在所选择的五种有机硫化合物中，PM对酪氨酸酶活性表现出显著的抑制作用（IC50 = 0.5 mM），并且对邻苯二酚形成具有最高的抑制作用。在B16细胞内模型系统中，所选择的五种有机硫化合物对酪氨酸酶活性和黑色素形成的抑制作用，部分可能归因于B16细胞中活性氧（ROS）形成的减少以及谷胱甘肽/氧化型谷胱甘肽（GSH/GSSG）比值的正向调节。在这五种有机硫化合物中，PM似乎是黑色素形成最有效的抑制剂。抑制动力学分析表明，PM是一种混合型抑制剂。这是第一项表明所测试的有机硫化合物可能在黑色素形成的调节中起重要作用的研究，使其成为美白剂的有力候选物。
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