寻找天然皮肤美白剂。
The hunt for natural skin whitening agents.
机构信息
Department of Clinical Chemistry, room L02-56, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
DermData, Prague, Czech Republic.
出版信息
Int J Mol Sci. 2009 Dec 10;10(12):5326-5349. doi: 10.3390/ijms10125326.
Abstract
Skin whitening products are commercially available for cosmetic purposes in order to obtain a lighter skin appearance. They are also utilized for clinical treatment of pigmentary disorders such as melasma or postinflammatory hyperpigmentation. Whitening agents act at various levels of melanin production in the skin. Many of them are known as competitive inhibitors of tyrosinase, the key enzyme in melanogenesis. Others inhibit the maturation of this enzyme or the transport of pigment granules (melanosomes) from melanocytes to surrounding keratinocytes. In this review we present an overview of (natural) whitening products that may decrease skin pigmentation by their interference with the pigmentary processes.
摘要
市面上有许多用于美容的皮肤美白产品，其目的是使肤色更浅。这些产品也被用于治疗色素紊乱，如黄褐斑或炎症后色素沉着过度。美白剂在黑色素生成的不同阶段发挥作用。其中许多是酪氨酸酶的竞争性抑制剂，酪氨酸酶是黑色素生成的关键酶。其他的则抑制该酶的成熟或黑素小体（黑色素颗粒）从黑素细胞向周围角质形成细胞的运输。在这篇综述中，我们介绍了（天然）美白产品，它们通过干扰色素形成过程来减少皮肤色素沉着。
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