Miyagawa S, Nishino N, Kamata R, Okamura R, Maeda H
Department of Microbiology, Kumamoto University Medical School, Japan.
Microb Pathog. 1991 Aug;11(2):137-41. doi: 10.1016/0882-4010(91)90007-w.
The growth inhibitory effects of chicken egg white ovomacroglobulin (ovoM) on Serratia marcescens and Pseudomonas aeruginosa were studied. The growth of protease-producing strains was greater than that of the strains producing little protease, and was inhibited in a dose-dependent manner by ovoM, a potent protease inhibitor. Dose-dependent enhancement of growth of strains of S. marcescens and P. aeruginosa that produce little protease was observed with the medium treated with proteases. These results indicate that extracellular proteases produced by the organisms augment their growth and that inhibition of the proteases results in suppression of growth.
研究了鸡卵清白蛋白（卵巨球蛋白，ovoM）对粘质沙雷氏菌和铜绿假单胞菌的生长抑制作用。产蛋白酶菌株的生长比产少量蛋白酶的菌株更强，并且受到强效蛋白酶抑制剂ovoM的剂量依赖性抑制。在用蛋白酶处理的培养基中，观察到少量产蛋白酶的粘质沙雷氏菌和铜绿假单胞菌菌株的生长呈剂量依赖性增强。这些结果表明，这些生物体产生的胞外蛋白酶促进了它们的生长，并且蛋白酶的抑制导致生长受抑制。
