Pieper Barbara, Templin Thomas N, Kirsner Robert S, Birk Thomas J
College of Nursing, Wayne State University, Detroit, Michigan 48202, USA.
Wound Repair Regen. 2009 Jul-Aug;17(4):485-91. doi: 10.1111/j.1524-475X.2009.00513.x.
We examined chronic venous disorders (CVD) in persons who injected illicit drugs. The study design was cross-sectional, comparative stratified by age, gender, ethnicity, as well as by three types of drug use (noninjection; arm or upper body injection only; and legs with or without upper body injection). Subjects completed demographic, health, and substances abuse questionnaires and were evaluated using the clinical component of the Clinical-Etiology-Anatomy-Pathophysiology Classification. Seven hundred and thirteen participants were evaluated. Those who injected in the legs +/- arms had significantly worse CVD. Thirty-nine percent of leg +/- arm injectors vs. 4.2% or noninjectors or arm only injectors had moderate to severe CVD. Persons who injected in the legs +/- arms were 9.14 times more likely to develop venous ulcers than those that injected in the arms and upper body only and 34.64 times more likely as those who never injected. CVD was associated with injecting in the groin, legs and feet as compared with other sites. The pattern of disorders associated with leg injection is consistent with the underlying pathology of chronic venous insufficiency.
我们对注射非法药物的人群进行了慢性静脉疾病（CVD）检查。研究设计为横断面研究，按年龄、性别、种族以及三种药物使用类型（非注射；仅手臂或上身注射；腿部注射，无论是否伴有上身注射）进行比较分层。受试者完成了人口统计学、健康状况和药物滥用调查问卷，并使用临床病因 - 解剖 - 病理生理学分类的临床部分进行评估。共评估了713名参与者。那些在腿部±手臂注射的人患有CVD的情况明显更糟。在腿部±手臂注射的人中，39%患有中度至重度CVD，而非注射者或仅在手臂注射者中这一比例为4.2%。与仅在上臂和上身注射的人相比，在腿部±手臂注射的人发生静脉溃疡的可能性高9.14倍，与从未注射过的人相比高34.64倍。与其他部位相比，CVD与在腹股沟、腿部和足部注射有关。与腿部注射相关的疾病模式与慢性静脉功能不全的潜在病理一致。
