College of Nursing, Wayne State University, 5557 Cass Avenue, Detroit, MI 48202, USA.
J Wound Ostomy Continence Nurs. 2011 Jan-Feb;38(1):46-54. doi: 10.1097/won.0b013e318202c47a.
The purpose of the study was to examine the symptom of itch and its relationship with chronic venous disease, pain, and quality of life.
The study used an exploratory, cross-sectional design.
One hundred and sixty-one participants completed demographic, health, substance abuse, itch, and pain questionnaires and the SF-12v2 Health Survey to measure health related quality of life.
Participants were mostly men (n=95, 59%), African American (113, 70.2%), and had a mean age of 44.19 years. A history of injection drug use was reported by 91.4%. Using the clinical score of the Clinical-Etiology-Anatomy-Pathophysiology (CEAP) Classification of the worst leg, the most common classification was Class 3, edema without skin changes (45.9%); 18.6% had severe venous disease (Classes 5 and 6). Eighty-eight participants (54.7%) reported itch somewhere on their body with 74 of them (45.9%) reporting itch on the legs or feet. Fourteen participants who reported itch of their legs or feet had wounds on the legs or feet. A positive correlation between magnitude of reported itch and CEAP clinical classification was noted (0.26, P =.025). This relationship was not strictly linear with itch increasing at a faster rate at higher levels of the CEAP classification. Persons with leg or feet itch had poorer health related quality of life, more comorbidities, and higher leg pain than those without itch. Because the SF-12v2 Health Survey is norm based, persons with itch were more than 1 standard deviation below the mean for the United States for their mental and physical health scores.
Itch on the legs or feet is a clinically relevant problem that is related to the level of venous disease. Persons with lower extremity itch have higher pain ratings and lower quality of life.
本研究旨在探讨瘙痒症状及其与慢性静脉疾病、疼痛和生活质量的关系。
本研究采用探索性、横断面设计。
161 名参与者完成了人口统计学、健康、药物滥用、瘙痒和疼痛问卷以及 SF-12v2 健康调查，以衡量与健康相关的生活质量。
参与者主要为男性（n=95，59%）、非裔美国人（n=113，70.2%），平均年龄为 44.19 岁。91.4%的人有注射药物使用史。根据最差腿部的临床评分临床-病因-解剖-病理生理学（CEAP）分类，最常见的分类是无皮肤改变的 3 级水肿（45.9%）；18.6%有严重的静脉疾病（5 级和 6 级）。88 名参与者（54.7%）报告身体某个部位有瘙痒，其中 74 名（45.9%）报告腿部或脚部有瘙痒。14 名报告腿部或脚部瘙痒的参与者腿部或脚部有伤口。报告的瘙痒严重程度与 CEAP 临床分类呈正相关（0.26，P=.025）。这种关系并不是严格线性的，CEAP 分类越高，瘙痒程度增加的速度越快。腿部或脚部瘙痒的人健康相关生活质量较差，合并症较多，腿部疼痛较高。由于 SF-12v2 健康调查是基于标准的，因此有瘙痒的人在心理健康和生理健康评分上比美国平均值低 1 个标准差以上。
腿部或脚部的瘙痒是一个具有临床意义的问题，与静脉疾病的严重程度有关。下肢瘙痒的人疼痛评分更高，生活质量更低。
