肺移植和心脏移植术后囊性纤维化患者感染Cirrosus 霉菌导致致命性侵袭性真菌血症
Fatal invasive infection with fungemia due to Microascus cirrosus after heart and lung transplantation in a patient with cystic fibrosis.
机构信息
Laboratoire de Parasitologie-Mycologie, CHU de Nantes, Nantes, France.
出版信息
J Clin Microbiol. 2011 Jul;49(7):2743-7. doi: 10.1128/JCM.00127-11. Epub 2011 May 4.
Abstract
Scopulariopsis species are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsis species, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis/Microascus infections are discussed.
摘要
曲霉属种在免疫功能低下的患者中是一种机会性致病菌，虽然罕见，但越来越受到重视。我们报告了一例囊性纤维化患者，在心肺移植后发生了罕见的曲霉属种——帚霉属中的Cirrosus 帚霉引起的播散性真菌感染。尽管采用伏立康唑和卡泊芬净的抗真菌联合治疗，患者在移植后 4 周死亡。本文讨论了播散性帚霉/曲霉属感染的诊断困难和最佳治疗方法。
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