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肺移植和心脏移植术后囊性纤维化患者感染Cirrosus 霉菌导致致命性侵袭性真菌血症

Fatal invasive infection with fungemia due to Microascus cirrosus after heart and lung transplantation in a patient with cystic fibrosis.

机构信息

Laboratoire de Parasitologie-Mycologie, CHU de Nantes, Nantes, France.

出版信息

J Clin Microbiol. 2011 Jul;49(7):2743-7. doi: 10.1128/JCM.00127-11. Epub 2011 May 4.

DOI:10.1128/JCM.00127-11
PMID:21543579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3147864/
Abstract

Scopulariopsis species are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsis species, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis/Microascus infections are discussed.

摘要

曲霉属种在免疫功能低下的患者中是一种机会性致病菌，虽然罕见，但越来越受到重视。我们报告了一例囊性纤维化患者，在心肺移植后发生了罕见的曲霉属种——帚霉属中的Cirrosus 帚霉引起的播散性真菌感染。尽管采用伏立康唑和卡泊芬净的抗真菌联合治疗，患者在移植后 4 周死亡。本文讨论了播散性帚霉/曲霉属感染的诊断困难和最佳治疗方法。

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本文引用的文献

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Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database.2001-2006 年造血干细胞移植受者侵袭性真菌感染的前瞻性监测：移植相关感染监测网络（TRANSNET）数据库概述。
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Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET).器官移植受者中的侵袭性真菌感染：移植相关感染监测网络（TRANSNET）的结果。
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Disseminated Scopulariopsis brevicaulis infection in an allogeneic stem cell recipient: case report and review of the literature.播散性短帚霉感染的异基因造血干细胞移植受者：病例报告及文献复习。
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Disseminated Scopulariopsis-culture is required to distinguish from other disseminated mould infections.需要进行播散性帚霉培养以与其他播散性霉菌感染相鉴别。
J Cutan Pathol. 2010 Jun;37(6):687-91. doi: 10.1111/j.1600-0560.2009.01358.x. Epub 2009 Jul 14.
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A fatal case of invasive fungal sinusitis by Scopulariopsis acremonium in a bone marrow transplant recipient.骨髓移植受者中由节菱孢霉引起的侵袭性真菌性鼻窦炎致死病例
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