Morooka Miyako, Kubota Kazuo, Kadowaki Hiromu, Ito Kimiteru, Okazaki Osamu, Kashida Mitsuo, Mitsumoto Takuya, Iwata Ren, Ohtomo Kuni, Hiroe Michiaki
Division of Nuclear Medicine, Department of Radiology, International Medical Center of Japan, Shinjuku-ku, Tokyo, Japan.
J Nucl Med. 2009 Aug;50(8):1283-7. doi: 10.2967/jnumed.108.061341. Epub 2009 Jul 17.
Tissue uptake of l-[methyl-(11)C]-methionine ((11)C-methionine) has been used to monitor amino acid metabolism and protein synthesis. We examined whether (11)C-methionine was retained in areas of myocardial infarction after successful reperfusion.
Nine patients with infarction in the left anterior descendent region underwent percutaneous transluminal coronary artery intervention within 24 h and (201)Tl SPECT, (18)F-FDG PET, and (11)C-methionine PET within 2 wk of infarction onset. The standardized uptake values of the infarcted area and of the normal area were measured.
The (11)C-methionine images showed increased uptake in the infarcted area, whereas the (201)Tl SPECT and (18)F-FDG PET images showed decreased uptake. The highest accumulation of (11)C-methionine in the infarcted area was observed during the early phase of AMI.
(11)C-methionine uptake is elevated in infarcted areas and may reflect the early acute phase of damage healing, that is, the initial process of remodeling.
L-[甲基-(11)C]-蛋氨酸（(11)C-蛋氨酸）的组织摄取已被用于监测氨基酸代谢和蛋白质合成。我们研究了成功再灌注后(11)C-蛋氨酸是否在心肌梗死区域潴留。
9例左前降支区域梗死患者在发病24小时内接受经皮腔内冠状动脉介入治疗，并在梗死发作后2周内进行(201)Tl单光子发射计算机断层扫描（SPECT）、(18)F-氟代脱氧葡萄糖（FDG）正电子发射断层扫描（PET）和(11)C-蛋氨酸PET检查。测量梗死区域和正常区域的标准化摄取值。
(11)C-蛋氨酸图像显示梗死区域摄取增加，而(201)Tl SPECT和(18)F-FDG PET图像显示摄取减少。在急性心肌梗死早期观察到梗死区域(11)C-蛋氨酸的最高蓄积。
梗死区域(11)C-蛋氨酸摄取升高，可能反映损伤愈合的早期急性期，即重塑的初始过程。
