Ratnoff O D, Everson B, Embury P, Ziats N P, Anderson J M, Emanuelson M M, Malemud C J
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10740-3. doi: 10.1073/pnas.88.23.10740.
The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation.
培养的人血管内皮细胞的上清液（条件培养基）可抑制哈格曼因子（因子 XII）的激活，无论是通过鞣花酸、牛脑硫脂还是碱式没食子酸铋；这种抑制作用似乎是培养上清液中一种或多种蛋白质的特性。这种现象可能通过抑制内源性凝血途径的表面激活来维持循环血液的流动性。
