人血管内皮细胞培养上清液对激活的哈格曼因子（因子XII）的抑制作用。
Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates.
作者信息
Ratnoff O D, Everson B, Embury P, Ziats N P, Anderson J M, Emanuelson M M, Malemud C J
机构信息
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
出版信息
Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10740-3. doi: 10.1073/pnas.88.23.10740.
Abstract
The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation.
摘要
培养的人血管内皮细胞的上清液（条件培养基）可抑制哈格曼因子（因子 XII）的激活，无论是通过鞣花酸、牛脑硫脂还是碱式没食子酸铋；这种抑制作用似乎是培养上清液中一种或多种蛋白质的特性。这种现象可能通过抑制内源性凝血途径的表面激活来维持循环血液的流动性。
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Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates.人血管内皮细胞培养上清液对激活的哈格曼因子（因子XII）的抑制作用。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Activation of Hageman factor (factor XII) by sulfatides and other agents in the absence of plasma proteases.在无血浆蛋白酶的情况下，硫酸脑苷脂及其他试剂对哈格曼因子（因子Ⅻ）的激活作用。
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Wasp sting anaphylaxis.黄蜂蜇伤过敏反应
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Inhibition of contact activation by platelet factor 4.血小板因子4对接触激活的抑制作用。
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Inhibition of the activation of Hageman factor (factor XII) by peripheral blood cells.外周血细胞对凝血因子 XII（哈格曼因子）激活的抑制作用。
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