哺乳动物内耳感觉上皮的再生。
Regeneration of the mammalian inner ear sensory epithelium.
作者信息
Wei Dongguang, Yamoah Ebenezer N
机构信息
Center for Neuroscience, Program in Communication Science, Department of Anesthesiology and Pain Medicine, University of California, Davis, California 95618, USA.
出版信息
Curr Opin Otolaryngol Head Neck Surg. 2009 Oct;17(5):373-80. doi: 10.1097/MOO.0b013e328330345b.
PURPOSE OF REVIEW
This review will focus on 'self-repair' of the mammalian inner ear sensory epithelium, including recruiting the in-situ proliferation and differentiation of endogenous cells at the damaged site and the autologous transplantation
RECENT FINDINGS
Self-repair refers to a favorable structural and functional outcome of damaged inner ear sensory epithelium. Our advanced ability of manipulating the fate of inner ear sensory cells makes in-situ proliferation a possible candidate of hearing restoration. A practical alternative of the unavoidable immune rejection is to introduce autologous cells. Ependymal cells, induced pluripotent stem cells, and olfactory neuroepithelial cells have been recognized as promising sources, which will spur ongoing efforts to evaluate these new cell sources for cell replacement therapy.
SUMMARY
Further exploration of the innate advantages of in-situ proliferation and use of novel cell sources for autologous transplantation may serve as rehearsals for clinical trials in the near future.
综述目的
本综述将聚焦于哺乳动物内耳感觉上皮的“自我修复”，包括促使受损部位内源性细胞的原位增殖和分化以及自体移植。
最新发现
自我修复指受损内耳感觉上皮的良好结构和功能结果。我们在操控内耳感觉细胞命运方面的先进能力使原位增殖成为听力恢复的一个可能选择。避免不可避免的免疫排斥的一个切实可行的替代方法是引入自体细胞。室管膜细胞、诱导多能干细胞和嗅神经上皮细胞已被认为是有前景的细胞来源，这将推动正在进行的评估这些新细胞来源用于细胞替代疗法的努力。
总结
进一步探索原位增殖的固有优势以及使用新型细胞来源进行自体移植可能为不久的将来的临床试验做好准备。
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