Ghosh Parasar, Kumar Amresh, Kumar Sudeep, Aggarwal Amita, Sinha Nakul, Misra Ramnath
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Clin Rheumatol. 2009 Nov;28(11):1259-65. doi: 10.1007/s10067-009-1228-6. Epub 2009 Jul 19.
Patients with systemic lupus erythematosus (SLE), especially Asian Indians, are at increased risk of developing premature atherosclerosis. To find out the prevalence and predictors of carotid intima-medial thickness (IMT) and brachial artery flow-mediated dilatation (FMD). Endothelial dysfunction was assessed by FMD in brachial artery and IMT was measured in common carotid artery in SLE patients and healthy controls. Sixty SLE patients (mean age 31 +/- 9 years) and 38 healthy controls (mean age 34 +/- 6 years) were included. The IMT was higher in SLE patients as compared to controls (0.49 +/- 0.08 mm vs. 0.39 +/- 0.05 mm, p < 0.0001). SLE and damage were independent predictors of abnormal IMT. FMD was impaired in SLE patients compared to controls (9.97% vs. 18.97%, p < 0.00001). None of the classical cardiovascular risk factors were predictors of FMD or abnormal IMT. Indian patients with SLE have higher prevalence of subclinical atherosclerosis and endothelial dysfunction. Presence of damage was associated with abnormal IMT in SLE patients.
系统性红斑狼疮（SLE）患者，尤其是亚洲印度裔患者，发生过早动脉粥样硬化的风险增加。为了明确颈动脉内膜中层厚度（IMT）和肱动脉血流介导的血管舒张功能（FMD）的患病率及预测因素。通过肱动脉FMD评估内皮功能障碍，并在SLE患者和健康对照者中测量颈总动脉的IMT。纳入了60例SLE患者（平均年龄31±9岁）和38例健康对照者（平均年龄34±6岁）。与对照组相比，SLE患者的IMT更高（0.49±0.08mm对0.39±0.05mm，p<0.0001）。SLE及损伤是IMT异常的独立预测因素。与对照组相比，SLE患者的FMD受损（9.97%对18.97%，p<0.00001）。经典的心血管危险因素均不是FMD或IMT异常的预测因素。印度SLE患者亚临床动脉粥样硬化和内皮功能障碍的患病率更高。SLE患者中损伤的存在与IMT异常相关。
