Endocrinology Division, Hospital Universitari Vall, d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain.
Obes Rev. 2010 Apr;11(4):322-8. doi: 10.1111/j.1467-789X.2009.00638.x. Epub 2009 Jul 10.
Iron is a necessary constituent of several macromolecules involved in cell metabolism, but, at the same time, it could be a potentially dangerous element. For this reason iron balance must be finely regulated. At present, obesity has been recognized as a worldwide public health problem. Excess body fat is associated with increased all-cause mortality and increased risk for several medical morbidities. Many studies have shown that obesity might increase the risk of iron deficiency but, at the same time, obese subjects exhibit high serum ferritin levels. Recent studies seem to indicate that obesity is associated with iron deficiency although the aetiology appears to be multifactorial and includes (i) A decrease in iron food intake; (ii) An impairment of intestinal iron uptake and iron release from stores because of an overexpression of hepcidin and (iii) Inadequate iron bioavailability because of inflammation. In addition, abnormal ferritin concentrations can be explained by chronic inflammation rather than by iron overload. The aim of the present article is to review current knowledge of iron and obesity.
铁是参与细胞代谢的几种大分子的必需成分，但同时，它也可能是一种潜在的危险元素。因此，铁的平衡必须得到精细的调节。目前，肥胖已被公认为是一个全球性的公共卫生问题。过多的体脂肪与全因死亡率的增加以及多种医疗并发症的风险增加有关。许多研究表明，肥胖可能会增加缺铁的风险，但同时，肥胖者的血清铁蛋白水平也很高。最近的研究似乎表明肥胖与缺铁有关，尽管其病因似乎是多因素的，包括：(i)铁的食物摄入量减少；(ii)由于铁调素的过度表达，肠道铁吸收和铁从储存中释放受损；(iii)由于炎症，铁的生物利用度不足。此外，铁蛋白浓度的异常可以用慢性炎症来解释，而不是铁过载。本文的目的是综述铁与肥胖的最新知识。
