Halliday J W, Mack U, Powell L W
Arch Intern Med. 1978 Jul;138(7):1109-13.
The relationship between serum ferritin and duodenal ferritin was examined in normal subjects and in patients with iron deficiency, secondary iron overload, or idiopathic hemochromatosis (IHC). A positive correlation between serum ferritin and duodenal ferritin concentrations was found in all groups. In the iron-overload conditions, duodenal ferritin concentration was lower at all levels of serum ferritin in comparison with normal and iron-deficient subjects. Patients with secondary iron overload did not differ from those with IHC, which indicates that any decrease in duodenal ferritin concentration was secondary to the excess body iron stores. Purified duodenal ferritin from normal subjects and patients with iron-overload conditions showed the same two distinct isoferritins by isoelectric focusing. After the oral administration of iron, two additional isoferritins were detected. These resembled the major isoferritins of liver.
在正常受试者以及患有缺铁、继发性铁过载或特发性血色素沉着症（IHC）的患者中，研究了血清铁蛋白与十二指肠铁蛋白之间的关系。在所有组中均发现血清铁蛋白与十二指肠铁蛋白浓度呈正相关。在铁过载情况下，与正常和缺铁受试者相比，在所有血清铁蛋白水平下十二指肠铁蛋白浓度均较低。继发性铁过载患者与IHC患者无差异，这表明十二指肠铁蛋白浓度的任何降低都是身体铁储存过量的继发结果。通过等电聚焦，来自正常受试者和铁过载情况患者的纯化十二指肠铁蛋白显示出相同的两种不同的异铁蛋白。口服铁剂后，检测到另外两种异铁蛋白。它们类似于肝脏的主要异铁蛋白。
