Human Nutrition Department, College of Health Sciences, Qu-Health, Qatar University, Doha, Qatar.
PLoS One. 2021 Apr 29;16(4):e0250759. doi: 10.1371/journal.pone.0250759. eCollection 2021.
Co-existence of iron deficiency and obesity in adults has been reported in many countries. However, little is known on the association between obesity and iron deficiency in Qatar. This study aimed to investigate the link between abdominal obesity indices and iron status among adults in Qatar. A random sample of 1000 healthy Qatari adults, aged 20-50 years, was obtained from Qatar Biobank study. Body weight, waist circumference, dual x-ray absorptiometry (DXA) parameters and iron status indicators were measured using standard techniques. Multiple regression analysis was used to examine the associations. The prevalence of iron deficiency and anaemia were 35.4 and 25%, respectively. Of the participants with a large waist circumference, 31.7% had anaemia. Ferritin significantly increased with the increase in the android fat to gynoid fat ratio and visceral fat in both genders. Serum iron and transferring saturation decreased significantly with the increase in waist circumference in women. In both genders, C-reactive protein increased with the increase in all obesity indices. Standardized values of waist circumference, android fat, gynoid fat ratio and visceral fat were significantly associated with log transformed ferritin in men and women. Waist circumference was inversely related to serum iron (β:-0.95, 95% CI:-1.50,-0.39) and transferrin saturation (β:-1.45, 95%CI:-2.46, -0.43) in women. In men, waist circumference was positively associated with haemoglobin level (β: 0.16, 95% CI:0.04, 0.29). Central obesity coexists with anaemia among the study population. Elevated central obesity indices were associated with an increase in ferritin concentration. The increased ferritin concentration may be attributed to the increase in inflammatory status as a result of an increase in c-reactive protein concentration associated with central obesity.
在许多国家都有报道称成年人同时存在铁缺乏和肥胖。然而，关于卡塔尔肥胖与铁缺乏之间的关系知之甚少。本研究旨在探讨卡塔尔成年人腹部肥胖指数与铁状况之间的关系。从卡塔尔生物银行研究中随机抽取了 1000 名年龄在 20-50 岁之间的健康卡塔尔成年人作为样本。使用标准技术测量体重、腰围、双能 X 线吸收法 (DXA) 参数和铁状态指标。采用多元回归分析来检验相关性。铁缺乏和贫血的患病率分别为 35.4%和 25%。在腰围较大的参与者中，有 31.7%患有贫血。在两性中，铁蛋白随着男性的安卓脂肪与女性的女性脂肪比例和内脏脂肪的增加而显著增加。血清铁和转铁饱和度在女性中随着腰围的增加而显著下降。在两性中，所有肥胖指数的增加都伴随着 C-反应蛋白的增加。腰围、安卓脂肪、女性脂肪比例和内脏脂肪的标准化值与男性和女性铁蛋白的对数转换值显著相关。腰围与女性血清铁（β：-0.95，95%CI：-1.50，-0.39）和转铁饱和度（β：-1.45，95%CI：-2.46，-0.43）呈负相关。在男性中，腰围与血红蛋白水平呈正相关（β：0.16，95%CI：0.04，0.29）。研究人群中存在中心性肥胖与贫血并存。中心性肥胖指数的升高与铁蛋白浓度的升高有关。铁蛋白浓度的升高可能归因于与中心性肥胖相关的 C-反应蛋白浓度增加导致炎症状态的增加。
