不断进化的核糖体：从非编码肽键形成到精密的翻译机制。

The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery.

作者信息

Davidovich Chen, Belousoff Matthew, Bashan Anat, Yonath Ada

机构信息

The Department of Structural Biology, Weizmann Institute, Rehovot, Israel.

出版信息

Res Microbiol. 2009 Sep;160(7):487-92. doi: 10.1016/j.resmic.2009.07.004. Epub 2009 Jul 18.

DOI:10.1016/j.resmic.2009.07.004

PMID:19619641

Abstract

Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome's active site is a universal symmetrical pocket made of ribosomal RNA. This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polymerization.

摘要

结构分析得到了生化、诱变和计算证据的支持，结果显示当代核糖体的活性位点是一个由核糖体RNA构成的通用对称口袋。这个口袋似乎是原始核糖体的残余部分，原始核糖体是一种通过基因复制进化而来的二聚体RNA组装体，能够自主催化肽键形成和非编码氨基酸聚合。