墨西哥慢性静脉疾病患者生活质量评估——口服刺路路通-橙皮苷甲基查耳酮-抗坏血酸治疗的影响——“质量研究”

Assessment of quality of life in Mexican patients suffering from chronic venous disorder - impact of oral Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid treatment - 'QUALITY Study'.

作者信息

Guex J J, Enriquez Vega D M E, Avril L, Boussetta S, Taïeb C

机构信息

Cabinet de Phlébologie, 32 Boulevard Dubouchage, 06000 Nice, France.

出版信息

Phlebology. 2009 Aug;24(4):157-65. doi: 10.1258/phleb.2009.008066.

DOI:10.1258/phleb.2009.008066

PMID:19620698

Abstract

OBJECTIVES

The present study assessed the effect of Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid (HMC-AA) on the quality of life (QoL) of patients suffering from chronic venous disorders (CVDs).

METHODS

An observational, multicentre and prospective study was performed with 917 Mexican patients suffering from CVD. Patients were treated with R. aculeatus-HMC-AA. After 12 weeks of treatment, the physicians then assessed the patients' symptoms and QoL using Short Form (SF-12) and Chronic Venous Insufficiency (CIVIQ) auto-questionnaires.

RESULTS

Patients were mainly women (86.7%), overweight or obese (72.7%) or C2 (39.3%)-C3 (27.6%). All symptoms and ankle circumferences significantly improved over time, with increasing clinical, aetiological, anatomical and pathophysiological (CEAP) classes and body mass index (BMI) (P < 0.001). Concerning QoL, all dimensions of the SF-12 score significantly improved over time (P < 0.001). Moreover, the CIVIQ scores significantly improved (P < 0.001) with increasing BMI (P < 0.002) and CEAP classes (P < 0.05).

CONCLUSION

R. aculeatus-HMC-AA significantly improved the symptoms and QoL of CVD patients.

摘要

目的

本研究评估了刺叶番荔枝 - 橙皮苷甲基查耳酮 - 抗坏血酸（HMC - AA）对慢性静脉疾病（CVD）患者生活质量（QoL）的影响。

方法

对917名患有CVD的墨西哥患者进行了一项观察性、多中心前瞻性研究。患者接受刺叶番荔枝 - HMC - AA治疗。治疗12周后，医生使用简短形式（SF - 12）和慢性静脉功能不全（CIVIQ）自动问卷评估患者的症状和生活质量。

结果

患者主要为女性（86.7%），超重或肥胖（72.7%），或C2（39.3%） - C3（27.6%）级。随着时间推移，所有症状和踝围均显著改善，临床、病因、解剖和病理生理（CEAP）分级及体重指数（BMI）增加（P < 0.001）。关于生活质量，SF - 12评分的所有维度随时间显著改善（P < 0.001）。此外，随着BMI增加（P < 0.002）和CEAP分级升高（P < 0.05），CIVIQ评分显著改善（P < 0.001）。