Allaert François-A
Int Angiol. 2016 Apr;35(2):111-6.
This paper focuses on Ruscus aculeatus extract (Ruscus extract) and its combination with hesperidin methyl chalcone (HMC) and ascorbic acid (AA), which have been safely and effectively used in CVD treatment for more than 50 years in some European countries. It presents the effects of that drug on veins and on venous hypertension, its effect on microcirculation and on lymphatics demonstrated by preclinical studies and the clinical evidence issued from clinical trials supporting its use to relieve the symptoms of venous disease. In addition to its venoconstrictive effect on veins, its pharmacological action is on the microcirculation impairment caused by venous hypertension that is at the heart of the pathophysiological mechanism underlying venous disease.
本文聚焦于刺叶番荔枝提取物（刺叶番荔枝提取物）及其与橙皮苷甲基查耳酮（HMC）和抗坏血酸（AA）的组合，在一些欧洲国家，它们已在心血管疾病治疗中安全有效地使用了50多年。本文介绍了该药物对静脉和静脉高压的作用，临床前研究证明了其对微循环和淋巴管的作用，以及临床试验提供的临床证据支持其用于缓解静脉疾病症状。除了对静脉的血管收缩作用外，其药理作用还针对由静脉高压引起的微循环损伤，而静脉高压是静脉疾病病理生理机制的核心。
