Vuylsteke M, Van Dorpe J, Roelens J, De Bo T, Mordon S
Department of Vascular Surgery, Sint-Andriesziekenhuis, Krommewalstraat 11, 8700 Tielt, Belgium.
Phlebology. 2009 Aug;24(4):166-75. doi: 10.1258/phleb.2009.008070.
The destruction induced during endovenous laser treatment (ELT) of the saphenous vein and the perivenous tissue in an animal model (goats) was analysed. Differences in vein wall destruction produced by two laser types, the 980 and 1500 nm diode lasers, were evaluated histologically.
In 14 goats, 28 lateral saphenous veins were treated with ELT. In 14 veins we used the 980 nm diode laser and in the remnant a 1500 nm laser. Postoperatively the veins were removed at different stages and sent for histological examination.
Immediately removed veins after ELT show an uneven destruction of the vein wall. Veins harvested one week postoperatively show inflammatory tissue at their periphery. Two and three weeks postoperatively, organization is very extensive. In some cases, recanalization begins in a semi-lunar manner at the contralateral side of the laser hit. Veins treated with a 980 nm laser show deeper ulceration with more perivenous tissue destruction compared with veins treated with a 1500 nm diode laser.
The ELT of veins produces an unevenly distributed damage. The cell necrosis is far more extensive than expected. Uneven vein wall destruction can lead to recanalization. Using a 1500 nm laser correlates with less penetrating ulcerations and more circumferential damage.
分析在动物模型（山羊）中隐静脉及静脉周围组织进行静脉内激光治疗（ELT）期间所引起的破坏情况。通过组织学方法评估两种激光类型，即980和1500纳米二极管激光，所产生的静脉壁破坏差异。
对14只山羊的28条外侧隐静脉进行ELT治疗。14条静脉使用980纳米二极管激光，其余的使用1500纳米激光。术后在不同阶段取出静脉并送去进行组织学检查。
ELT后立即取出的静脉显示静脉壁破坏不均匀。术后一周取出的静脉在其周边显示有炎性组织。术后两周和三周，机化非常广泛。在某些情况下，再通以半月形方式在激光照射的对侧开始。与使用1500纳米二极管激光治疗的静脉相比，使用980纳米激光治疗的静脉显示出更深的溃疡，静脉周围组织破坏更多。
静脉的ELT产生分布不均匀的损伤。细胞坏死比预期的广泛得多。静脉壁破坏不均匀可导致再通。使用1500纳米激光与较少穿透性溃疡和更多环形损伤相关。
