Burke Andrew, Ding Xuanfeng, Singh Ravi, Kraft Robert A, Levi-Polyachenko Nicole, Rylander Marissa Nichole, Szot Chris, Buchanan Cara, Whitney Jon, Fisher Jessica, Hatcher Heather C, D'Agostino Ralph, Kock Nancy D, Ajayan P M, Carroll David L, Akman Steven, Torti Frank M, Torti Suzy V
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12897-902. doi: 10.1073/pnas.0905195106. Epub 2009 Jul 20.
Multiwalled carbon nanotubes (MWCNTs) exhibit physical properties that render them ideal candidates for application as noninvasive mediators of photothermal cancer ablation. Here, we demonstrate that use of MWCNTs to generate heat in response to near-infrared radiation (NIR) results in thermal destruction of kidney cancer in vitro and in vivo. We document the thermal effects of the therapy through magnetic resonance temperature-mapping and heat shock protein-reactive immunohistochemistry. Our results demonstrate that use of MWCNTs enables ablation of tumors with low laser powers (3 W/cm(2)) and very short treatment times (a single 30-sec treatment) with minimal local toxicity and no evident systemic toxicity. These treatment parameters resulted in complete ablation of tumors and a >3.5-month durable remission in 80% of mice treated with 100 microg of MWCNT. Use of MWCNTs with NIR may be effective in anticancer therapy.
多壁碳纳米管（MWCNTs）具有一些物理特性，使其成为作为光热癌症消融的非侵入性介质应用的理想候选者。在此，我们证明，利用MWCNTs响应近红外辐射（NIR）产生热量会导致体外和体内肾癌的热破坏。我们通过磁共振温度映射和热休克蛋白反应性免疫组织化学记录了该疗法的热效应。我们的结果表明，使用MWCNTs能够以低激光功率（3 W/cm²）和非常短的治疗时间（单次30秒治疗）消融肿瘤，局部毒性最小且无明显全身毒性。这些治疗参数导致肿瘤完全消融，并且在接受100微克MWCNT治疗的小鼠中，80%实现了超过3.5个月的持久缓解。将MWCNTs与NIR结合使用可能在抗癌治疗中有效。
