Gao Wei, Zhang Weihao, Yu Haipeng, Xing Wenge, Yang Xueling, Zhang Yongguang, Liang Chunyong
Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Front Bioeng Biotechnol. 2022 Sep 19;10:996177. doi: 10.3389/fbioe.2022.996177. eCollection 2022.
MXene nanosheets have shown exciting potential in nanomedicine because of their large surface area, intense near-infrared (NIR) absorbance, and good biocompatibility. However, their development in the direction of treating tumors is constrained by the limitations of existing design methodologies. These methodologies lack control over the size and distribution of tumors. Moreover, their photodynamic therapy (PDT) effect is poor. To address this unmet medical need, a simple strategy that processes MXene with carbon nanotube (CNT) into a three-dimensional (3D) honeycomb structure having anti aggregation capacity was established. The structure can be used in disease phototherapy against tumors, bacteria, and viruses, such as photothermal therapy (PTT), photodynamic therapy (PDT), and multimodal synergistic therapy. In the present study, 3D CNT/MXene microspheres were obtained by the template method and spray-drying method. The microspheres possessed special photothermal effects and photothermal stability under NIR laser irradiation. Furthermore, the developed microspheres could achieve a maximum of 85.6% drug loading capability of doxorubicin (DOX). Under light irradiation at 650 and 808 nm, 3D CNT/MXene microspheres could efficiently produce singlet oxygen due to the effectiveness of CNTs as carries for Titanium Dioxide (TiO) photosensitizers present on the MXene surface. Furthermore, studies had showed that 3D CNT/MXene-DOX effectively inhibited the proliferation of HeLa cells. Hence, this study provides a promising platform for future clinical applications to realize PTT/PDT/chemotherapy combination cancer treatment based on MXene.
MXene纳米片由于其大表面积、强烈的近红外（NIR）吸收能力和良好的生物相容性，在纳米医学领域展现出了令人兴奋的潜力。然而，它们在肿瘤治疗方向上的发展受到现有设计方法局限性的制约。这些方法缺乏对肿瘤大小和分布的控制。此外，它们的光动力疗法（PDT）效果不佳。为了满足这一未被满足的医疗需求，建立了一种简单的策略，即将MXene与碳纳米管（CNT）加工成具有抗聚集能力的三维（3D）蜂窝结构。该结构可用于针对肿瘤、细菌和病毒的疾病光疗，如光热疗法（PTT）、光动力疗法（PDT）和多模态协同疗法。在本研究中，通过模板法和喷雾干燥法获得了3D CNT/MXene微球。这些微球在近红外激光照射下具有特殊的光热效应和光热稳定性。此外，所制备的微球对阿霉素（DOX）的载药能力最高可达85.6%。在650和808nm的光照射下，由于碳纳米管作为MXene表面存在的二氧化钛（TiO）光敏剂载体的有效性，3D CNT/MXene微球能够有效地产生单线态氧。此外，研究表明3D CNT/MXene-DOX能有效抑制HeLa细胞的增殖。因此，本研究为未来基于MXene实现PTT/PDT/化疗联合癌症治疗的临床应用提供了一个有前景的平台。
