Ataseven Hilmi, Oztürk Zeynel Abidin, Arhan Mehmet, Yüksel Osman, Köklü Seyfettin, Ibiş Mehmet, Başar Omer, Yilmaz Fatma Meriç, Yüksel Ilhami
Department of Gastroenterology, Erzurum Bölge Egitim ve Araştirma Hastanesi, Erzurum, Turkey.
J Clin Lab Anal. 2009;23(4):244-8. doi: 10.1002/jcla.20323.
Cancer antigen 125 (CA-125) is a tumor marker used for the diagnosis and monitoring of ovarian carcinoma. It can also be elevated in endometriosis, inflammations, and in nongynecological malignancies. Up to date, serum CA-125 levels in inflammatory bowel diseases (IBD) have not been studied before.
To assess the levels of CA-125 in patients with ulcerative colitis (UC) and Crohn's disease (CD).
Serum levels of CA-125 were investigated in 68 cases with UC (male/female: 47/21), 32 CD (male/female: 21/11), and 31 healthy controls (male/female: 16/15). Levels of CA-125 were also compared among UC patients according to lesion location, severity, and activity of CD.
Serum CA-125 levels were 17.29+/-24.50 U/ml, 15.56+/-20.74 U/ml, and 8.85+/-2.62 U/ml in patients with UC, CD, and healthy controls, respectively. Serum CA-125 levels were significantly higher in UC compared to control group (P=0.001). Serum CA-125 levels were higher in CD patients compared to control group but there was no significance (P=0.087). Serum CA-125 levels were higher in pancolitis compared to distal type and left-sided UC.
Our data suggest that serum CA-125 levels may be increased in patients with IBDs.
癌抗原125（CA-125）是一种用于卵巢癌诊断和监测的肿瘤标志物。它在子宫内膜异位症、炎症及非妇科恶性肿瘤中也可能升高。迄今为止，炎症性肠病（IBD）患者的血清CA-125水平尚未得到研究。
评估溃疡性结肠炎（UC）和克罗恩病（CD）患者的CA-125水平。
对68例UC患者（男/女：47/21）、32例CD患者（男/女：21/11）和31例健康对照者（男/女：16/15）的血清CA-125水平进行了研究。还根据UC患者的病变部位、严重程度及CD的活动度对CA-125水平进行了比较。
UC患者、CD患者和健康对照者的血清CA-125水平分别为17.29±24.50 U/ml、15.56±20.74 U/ml和8.85±2.62 U/ml。UC患者的血清CA-125水平显著高于对照组（P = 0.001）。CD患者的血清CA-125水平高于对照组，但无统计学意义（P = 0.087）。全结肠炎患者的血清CA-125水平高于远端型和左侧UC患者。
我们的数据表明，IBD患者的血清CA-125水平可能升高。
