确诊慢性疲劳综合征患者血清中的抗心磷脂抗体。
Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome.
作者信息
Hokama Yoshitsugi, Campora Cara Empey, Hara Cynthia, Kuribayashi Tina, Le Huynh Diana, Yabusaki Kenichi
机构信息
Department of Pathology, John A. Burns School of Medicine, University of Hawaii at Mânoa, Honolulu, Hawaii 96822, USA.
出版信息
J Clin Lab Anal. 2009;23(4):210-2. doi: 10.1002/jcla.20325.
Abstract
Examination of anticardiolipin antibodies (ACAs) in the sera of patients clinically diagnosed with chronic fatigue syndrome (CFS) using an enzyme-linked immunoassay procedure demonstrated the presence of immunoglobulin M isotypes in 95% of CFS serum samples tested. The presence of immunoglobulin G and immunoglobulin A isotypes were also detected in a subset of the samples. Future studies will focus on elucidating whether alterations to mitochondrial inner membranes and/or metabolic functions play a possible role in the expression of ACAs.
摘要
采用酶联免疫分析法对临床诊断为慢性疲劳综合征（CFS）患者血清中的抗心磷脂抗体（ACA）进行检测，结果显示，在95%的CFS血清检测样本中存在免疫球蛋白M亚型。在部分样本中还检测到了免疫球蛋白G和免疫球蛋白A亚型。未来的研究将集中于阐明线粒体内膜和/或代谢功能的改变是否在ACA的表达中发挥可能的作用。
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