[微小RNA在先天性免疫机制调控中的作用]

[Role of microRNA in regulation of innate immunity mechanisms].

作者信息

Koval'chuk L V, Gankovskaia L V, Akimova E A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 2009 May-Jun(3):100-4.

PMID:19623720

Abstract

New class of regulatory molecules--microRNA--is of special interest now. Large amount of data about function of these molecules in immune response regulation is accumulated. Functions of several microRNA molecules (miRNA-146, miRNA-155, miRNA-223) contributing to such mechanisms of innate immunity regulation as transmission of signals from receptors, maturation, differentiation and proliferation of innate immunity cells are described in this review. It is necessary to underline the perspective of these molecules for development of drugs for correction of innate immunity abnormalities.

摘要

一类新的调节分子——微小RNA——目前备受关注。关于这些分子在免疫反应调节中功能的大量数据正在积累。本综述描述了几种微小RNA分子（miRNA - 146、miRNA - 155、miRNA - 223）在先天免疫调节机制中的作用，如从受体传递信号、先天免疫细胞的成熟、分化和增殖。有必要强调这些分子在开发用于纠正先天免疫异常的药物方面的前景。