miR-146a 前体 C/G 多态性与中国人群胃癌风险的相关性。
Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population.
机构信息
Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
出版信息
World J Gastroenterol. 2010 Jul 28;16(28):3578-83. doi: 10.3748/wjg.v16.i28.3578.
AIM
To investigate the association between pre-miR-146a C/G polymorphism and gastric cancer risk.
METHODS
We performed a hospital-based, case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals (304 gastric cancer patients and 304 age and sex matched cancer-free controls).
RESULTS
The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups (P = 0.037). Compared with CC genotype carriers, subjects with the variant genotypes (GC + GG) had a 58% increased risk of gastric cancer (adjusted OR = 1.58, 95% CI: 1.11-2.20, P = 0.009). Moreover, a higher gastric cancer risk was especially evident in younger individuals aged < or =58 years, nonsmokers, and males (adjusted OR = 1.76, 95% CI: 1.08-2.87, P = 0.024; adjusted OR = 1.55, 95% CI: 1.06-2.28, P = 0.025; adjusted OR = 1.53, 95% CI: 1.04-2.27, P = 0.033; respectively).
CONCLUSION
Pre-miR-146a C/G polymorphism might be associated with an elevated risk of gastric cancer in Chinese population.
目的
探讨前 miR-146a C/G 多态性与胃癌风险的关联。
方法
采用聚合酶链反应-限制性片段长度多态性方法，对 608 例个体（304 例胃癌患者和 304 例年龄和性别匹配的无癌对照）进行了基于医院的病例对照研究。
结果
病例组中前 miR-146a C/G 基因型的频率与对照组有显著差异（P = 0.037）。与 CC 基因型携带者相比，变异基因型（GC+GG）个体患胃癌的风险增加了 58%（调整后的 OR = 1.58，95%CI：1.11-2.20，P = 0.009）。此外，在年龄≤58 岁、不吸烟者和男性中，胃癌的风险更高（调整后的 OR = 1.76，95%CI：1.08-2.87，P = 0.024；调整后的 OR = 1.55，95%CI：1.06-2.28，P = 0.025；调整后的 OR = 1.53，95%CI：1.04-2.27，P = 0.033）。
结论
前 miR-146a C/G 多态性可能与中国人群胃癌风险升高有关。
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