State Key Laboratory of Plant Genomics, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang, Hebei 050021, China.
University of the Chinese Academy of Sciences, Beijing 100049, China.
Plant Cell. 2018 Nov;30(11):2779-2794. doi: 10.1105/tpc.18.00297. Epub 2018 Oct 18.
Innate immunity plays a vital role in protecting plants and animals from pathogen infections. Immunity varies with age in both animals and plants. However, little is known about the ontogeny of plant innate immunity during seedling development. We report here that the Arabidopsis () microRNA miR172b regulates the transcription of the immune receptor gene () through TARGET OF EAT1 (TOE1) and TOE2, which directly bind to the promoter and inhibit its activity. The level of miR172b is very low in the early stage of seedling development but increases over time, which results in decreased TOE1/2 protein accumulation and, consequently, increased transcription and the ontogeny of FLS2-mediated immunity during seedling development. Our study reveals a role for the miR172b-TOE1/2 module in regulating plant innate immunity and elucidates a regulatory mechanism underlying the ontogeny of plant innate immunity.plantcell;30/11/2779/FX1F1fx1.
先天免疫在保护动植物免受病原体感染方面起着至关重要的作用。免疫在动物和植物中都随年龄而变化。然而，关于幼苗发育过程中植物先天免疫的个体发生知之甚少。我们在这里报告，拟南芥（Arabidopsis）miR172b 通过 TARGET OF EAT1（TOE1）和 TOE2 调节免疫受体基因（）的转录，这两个因子可直接结合到 启动子并抑制其活性。在幼苗发育的早期阶段，miR172b 的水平非常低，但随着时间的推移会增加，这导致 TOE1/2 蛋白积累减少，进而导致 转录增加以及 FLS2 介导的免疫的个体发生增加。我们的研究揭示了 miR172b-TOE1/2 模块在调节植物先天免疫中的作用，并阐明了植物先天免疫个体发生的调控机制。
