上海和斯德哥尔摩艰难梭菌的不同核糖型和抗生素耐药率。
Distinct ribotypes and rates of antimicrobial drug resistance in Clostridium difficile from Shanghai and Stockholm.
机构信息
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
出版信息
Clin Microbiol Infect. 2009 Dec;15(12):1170-3. doi: 10.1111/j.1469-0691.2009.02992.x. Epub 2009 Jul 15.
Seventy-five clinical isolates of Clostridium difficile from Shanghai and 80 from Stockholm were investigated. The prevalence of toxin A-negative, toxin B-positive isolates of C. difficile among isolates from Shanghai (33.3%) was significantly higher than among isolates from Stockholm (0%). Both sets of isolates were fully susceptible to metronidazole and vancomycin. However, the MICs of fluoroquinolones, erythromycin-clindamycin, tetracycline, rifampin and fusidic acid were significantly higher for the Shanghai isolates than for the Stockholm isolates. Thirty-three PCR ribotypes were identified; a dominant clone, 017, accounted for 18.7% of Shanghai isolates, whereas clone 005 dominated among Stockholm isolates, accounting for 11.3%. Strains 027 and 078 were not detected. No outbreak occurred during the study period.
对来自上海的 75 株艰难梭菌临床分离株和来自斯德哥尔摩的 80 株艰难梭菌临床分离株进行了研究。上海分离株中毒素 A 阴性、毒素 B 阳性的艰难梭菌的流行率（33.3%）显著高于斯德哥尔摩分离株（0%）。两组分离株均对甲硝唑和万古霉素完全敏感。然而，上海分离株对氟喹诺酮类、红霉素-克林霉素、四环素、利福平和夫西地酸的 MIC 值明显高于斯德哥尔摩分离株。鉴定出 33 种 PCR 核糖体分型；一个优势克隆，017，占上海分离株的 18.7%，而克隆 005在斯德哥尔摩分离株中占主导地位，占 11.3%。未检测到菌株 027 和 078。在研究期间未发生暴发。
Zotero 插件